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aspartic acid

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aspartic acid (əspär`tĭk), organic compound, one of the 20 amino acids amino acid (əmē`nō)
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 commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of proteins. Its acidic side chain adds a negative charge and hence a greater degree of water-solubility to proteins in neutral solution and has been shown to be near the active sites of some enzymes (see pepsin pepsin, enzyme produced in the mucosal lining of the stomach that acts to degrade protein. Pepsin is one of three principal protein-degrading, or proteolytic, enzymes in the digestive system , the other two being chymotrypsin and trypsin .
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). Aspartic acid is not essential to the human diet. It was discovered in protein in 1868.

aspartic acid

One of the nonessential amino acids, found in many proteins and closely related to asparagine. It is used in medical and biochemical research, as an organic intermediate, and in various industrial applications. It is one of the two components of aspartame.



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Lau hypothesizes that ingestion of the well-established neurotoxicants aspartic acid and L-glutamic acid as additives could lead to a high enough body burden to kill neurons by a mechanism called excitotoxicity.
The nucleotide changes at positions 1397, 1407, and 1481 resulted in amino acid substitutions (with 94% identity to Malaysia, 56 of 59) from isoleucine to valine, glycine to glutamic acid, and asparagine to aspartic acid at codons 429, 432, and 457 of N protein, respectively.
A synthetic derivative of a combination of aspartic acid and phenylalanine, the same two amino acids that are used to make aspartame.
 
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