asthma

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Related to atopic asthma: atopic dermatitis, intrinsic asthma

asthma

(ăz`mə, ăs`–), chronic inflammatory respiratory disease characterized by periodic attacks of wheezing, shortness of breath, and a tight feeling in the chest. A cough producing sticky mucus is symptomatic. The symptoms often appear to be caused by the body's reaction to a trigger such as an allergen (commonly pollen, house dust, animal dander: see allergyallergy,
hypersensitive reaction of the body tissues of certain individuals to certain substances that, in similar amounts and circumstances, are innocuous to other persons. Allergens, or allergy-causing substances, can be airborne substances (e.g.
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), certain drugs, an irritant (such as cigarette smoke or workplace chemicals), exercise, or emotional stress. These triggers can cause the asthmatic's lungslungs,
elastic organs used for breathing in vertebrate animals, excluding most fish, which use gills, and a few amphibian species that respire through the skin. The word is sometimes applied to the respiratory apparatus of lower animals.
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 to release chemicals that create inflammation of the bronchial lining, constriction, and bronchial spasms. If the effect on the bronchi becomes severe enough to impede exhalation, carbon dioxide can build up in the lungs and lead to unconsciousness and death. Following a steady 30-year decline, asthma deaths in the United States, especially among poor, inner-city blacks and among the elderly, began to rise from the late 1970s through the early 1990s. At the same time, the incidence of asthma also increased, both nationally and worldwide.

There is no cure for asthma. Although the disease may go through a period of quiescence, it appears that childhood asthmatics do not outgrow the disease as previously believed. Treatment includes inhaled or oral steroids or bronchodilators (albuterol, theophylline), breathing exercises, and, if possible, the identification and avoidance of triggers.

asthma

[′az·mə]
(medicine)
A pulmonary disease marked by labored breathing, wheezing, and coughing; cause may be emotional stress, chemical irritation, or exposure to an allergen.

asthma

a respiratory disorder, often of allergic origin, characterized by difficulty in breathing, wheezing, and a sense of constriction in the chest
References in periodicals archive ?
This clinical study found that the level of airway inflammation in children with atopic asthma was reduced, and that Plasmacluster Ion technology(2) will contribute to human health in an actual living environment.
The findings indicate that there is a potential for Plasmacluster Ion technology to reduce the level of airway inflammation in pediatric patients with mild or moderate atopic asthma.
Despite the increased risk of atopic asthma in a child of a mother with a doctor diagnosis of asthma (OR 4.
Also, despite asthma disease expression having an inherited or genetic component, maternal atopy (positive SPT and an allergic disease process), a history of symptoms suggestive of allergic diseases and a history of maternal asthma were not good predictors of atopic asthma in children, raising questions about the uniform association between allergy and asthma, especially in Africa, and suggesting that asthma may be associated with other aetiological factors.
Given that atopic asthma is the form of the disease that appears largely responsible for the childhood asthma epidemic and is a chronic disease that greatly affects quality of life, the study points to the need for preventive measures, the authors state.
IgE-mediated allergic inflammation is the central mechanism involved in the pathogenesis of atopic asthma (Busse and Lemanske 2001).
The role of particulate matter in exacerbation of atopic asthma.
As we continue to develop clinical applications for PreHistin(TM) to treat allergies, as well as atopic asthma, atopic migraine and other diseases triggered by IgE (Immunoglobulin E) overproduction, our expanding base of international patents adds tremendous value to our growing product portfolio and to our Company.
Researchers concluded that leptin may play an important role in the regulation of allergic inflammation in children with atopic asthma.
Scientists from McGill University and Magainin presented findings further demonstrating the importance of IL9 in the pathogenesis of asthma, including data identifying IL9 as a possible marker in human atopic asthma.
We are continuing our research and plan to publish additional data which will further demonstrate that this pathway is a key player in the pathogenesis of atopic asthma.
The Magainin team is working to dissect the interleukin-9 pathway and clone genes that represent potentially good targets for small molecule drug discovery efforts to treat atopic asthma.