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Related to atrophic: atrophic rhinitis, atrophic gastritis, atrophic kidney


(ăt`rəfē), diminution in the size of a cell, tissue, or organ from its fully developed normal size. Temporary atrophy may occur in muscles that are not used, as when a limb is encased in a plaster cast. Interference with cellular nutrition, as through starvation; diseases affecting the nerve supply of tissues, e.g., poliomyelitis and muscular dystrophy; and prolonged disuse may cause a permanent wasting away of tissue. Atrophy may also follow hypertrophyhypertrophy
, enlargement of a tissue or organ of the body resulting from an increase in the size of its cells. Such growth accompanies an increase in the functioning of the tissue. In normal physiology the growth in size of muscles (e.g.
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the decrease in the size of an organ or tissue of the living organism of animals and man, accompanied by a disorder or cessation of functions. Atrophy is the result of a predominance of dissimilation over the processes of assimilation.

Atrophy can be physiological and pathological, systemic and local. Physiological atrophy is a function of the growth changes of an organism (atrophy of the thymus during puberty, atrophy of the sex glands, skin, and bones in old people, and so on). General pathological atrophy (emaciation, cachexia) appears in cases of insufficient nutrition, chronic infection or intoxication, or disorders of the endocrine glands or of the central nervous system. Local pathological atrophy arises from various causes—from a disorder in the regulation of the trophic nerves (for example, atrophy of the skeletal muscles during poliomyelitis), from insufficient supply of blood (for example, atrophy of the brain cortex during atherosclerosis of the blood vessels of the brain); dysfunctional atrophy (for example, atrophy of the optic nerve after removal of an eye), as a result of pressure (for example, atrophy of the kidney in cases of embolism of the urether and accumulation of urine in the renal pelvis), from lack of use (for example, atrophy of the muscles in the extremities after long immobilization), or from the effects of physiological and chemical factors (for example, atrophy of the lymphoid tissue from the effects of solar energy, atrophy of the thyroid gland upon application of iodine preparations).

When an organ atrophies it diminishes in size but subsequently sometimes appears larger as a result of the expansion of fat tissue which replaces the atrophied cellular elements. Pathological atrophy is, up to a certain stage, a reversible process. Treatment consists of the elimination of the causes producing atrophy.


Strukov, A. I. Patologicheskaia anatomiia. Moscow, 1967.
Cameron, G. R. Pathology of the Cell. Edinburgh, 1952.



Diminution in the size of a cell, tissue, or organ that was once fully developed and of normal size.


a wasting away of an organ or part, or a failure to grow to normal size as the result of disease, faulty nutrition, etc.
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Closure of the nasal vestibule in atrophic rhinitis--a new non-surgical technique.
Although further studies on larger populations are needed, "we strongly suggest that women with atrophic Pap smear patterns be closely followed as recommended by the American National Osteoporosis Foundation," according to Dr.
Endoscopic nasal examination revealed an abnormally patent, empty nose anteriorly with a subtotal perforation of the nasal septum and atrophic inferior and middle turbinates (figure, C).
The randomized, double-blinded, multi-center, controlled study evaluated subjects to determine the safety and efficacy of ArteFill for the treatment of moderate to severe atrophic acne scars.
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It stands for Drugs, Infection, Atrophic vaginitis, Psychological factors, Endocrine causes, Restricted mobility, and Stool impaction, she explained at the annual clinical nephrology conference sponsored by the National Kidney Foundation.
Whether the lips are atrophic or just naturally thin, Dr.
The acute phase is followed by the chronic inflammatory phase, which is characterized by atrophic epithelium, intense pruritus, and a superinfection accompanied by acute dermatitis.
today announced the initiation of a Phase II clinical trial by the National Eye Institute (NEI) of Othera's topical eye drop OT-551 in patients with Geographic Atrophy (GA), a sign of dry or atrophic Age-Related Macular Degeneration (AMD).
Some leading researchers are therefore hypothesizing that these changes may induce atrophic changes in the mucosa of the vulvar vestibule, leading to discomfort and pain with sex; similar to menopausal women.
In 1957, Brunsting and Perry described a type of cicatricial pemphigoid that was characterized by recurrent, circumscribed, chronically progressing vesicobullous eruptions of the head and neck that caused atrophic scarring.
7 /PRNewswire/ -- Suneva Medical, a privately-held aesthetic medical device company, today announced the publication of an open-label, single center, pilot study on Artefill for the treatment of atrophic acne scars conducted by James M.