attenuated vaccine


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Related to attenuated vaccine: inactivated vaccine

attenuated vaccine

[ə′ten·yə‚wād·əd ‚vak′sēn]
(immunology)
A suspension of weakened bacteria, viruses, or fractions thereof used to produce active immunity.
References in periodicals archive ?
the replacement of 1 000 000 doses of live attenuated vaccine against CSF, if depleted (due to the vaccine shelf life expiry or its delivery to any place referred to in point 3.
Farthing argues that a live attenuated vaccine is me only one that can succeed against HIV.
Previous studies have shown that genetic recombination occurs between attenuated vaccine strains of PRRSV grown together in culture (14).
Clinical experience with live, attenuated vaccine in children.
In addition, the plasmids encoding the genes from the attenuated vaccine donor strain are available, and only the HA and NA genes need to be cloned for each vaccine.
The live attenuated vaccine induces both cellular and humoral immunity, but its use allows exchange of genetic material and recombination between coronaviruses--and generation of new infectious strains could be of considerable concern with a human vaccine.
Antibody-mediated protection against Brucella abortus in BALB/c mice at successive periods after infection: variation between virulent strain 2308 and attenuated vaccine strain 19.
This technology is applicable to any virus amenable to recombinant production, and allows for the generation of viruses which can be efficiently propagated in one species and used as a live attenuated vaccine in another.
Parallels drawn from animal models suggest that a live, attenuated vaccine may be more successful than a killed-virus vaccine, and that vaccines can enhance the disease process instead of protecting against infection, Dr.
Our portfolio includes patents for three different attenuated vaccine strains of Listeria and two different families of fusion proteins.
Efforts to develop a live, attenuated vaccine have thus far been disappointing: Once researchers at the NIAID identified the genes and created a vaccine designed to weaken it, experiments in monkeys revealed that the virus mutated, and infectious particles in feces from the monkeys were capable of causing hepatitis in other monkeys.
The currently available live, attenuated vaccine (17D vaccine) was developed in 1936 and approximately 30 million people traveling to or living in endemic regions are vaccinated annually.