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vaccine
(redirected from attenuated vaccine)

    Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.03 sec.

vaccine

Preparation containing either killed or weakened live microorganisms or their toxins, introduced by mouth, by injection, or by nasal spray to stimulate production of antibodies against an infectious agent. This confers immunity to that agent, since the B lymphocytes remain sensitized to it and respond to later infection by producing more antibodies. The first vaccine, against smallpox, was introduced by Edward Jenner in 1798. Vaccines have been developed against diseases caused by bacteria (e.g., typhoid, whooping cough, tuberculosis) and by viruses (e.g., measles, influenza, rabies, poliomyelitis). Effectiveness varies, and a small percentage of people have adverse reactions. Those with immunodeficiency disorders should not receive live vaccines.
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? Mentioned in ? References in periodicals archive
 
Subsequent studies performed in children found no significant difference in shedding of attenuated vaccine strains in patients who had recovered from previous infection with a vaccine or natural strain of a different subtype than did study participants who had no evidence of previous virus exposure (15,16).
Prospects for universal influenza virus vaccine by Zharikova, Darya / Emerging Infectious Diseases
The major advantage is that vaccines generated using this delivery system are much safer than live attenuated vaccines and very cost effective for mass administration," Lamb said.
AVIAN INFLUENZA VACCINE TRIALS INITIATED IN AUSTRALIA by Worldwide Biotech
Nevertheless, some scientists haven't given up on a live attenuated vaccine.
Prospects Dim for Live AIDS Vaccine by Seppa, N. / Science News
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