autoantigen


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autoantigen

[¦ȯd·ō′ant·i·jən]
(immunology)
A tissue within the body which acquires the ability to incite the formation of complementary antibodies.
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References in periodicals archive ?
Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2.
Determination of three major islet autoantigens - insulin, GAD65, and ICA512 (IA-2) - has become central component of studies of the natural history of DM.
Since the establishment for the technique of hybridoma formation by Kohler and Milstein, (64) many laboratories have engaged in producing hybridomas from autoimmune disease model animals to evaluate the relation between autoantigens and a single molecule of autoantibody: a certain laboratories intended to produce monoclonal antibodies by immunization of normal animals such as rabbits with their interest molecules to analyze the molecular dynamics biochemically.
Some of the autoantigens involved in the pathogenesis of RA include IgG, collagen, proteoglycan, citrullinated proteins, fibrin, fibrinogen, and the shared human leukocyte antigen (HLA) DR epitope [6, 7].
Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen [beta]2-glycoprotein i," Arthritis and Rheumatism, vol.
Maspin may function as an autoantigen in HLA-Cw6-associated T-cell-mediated psoriasis [36].
Chen's team demonstrated that both the macrophages and the autoantigens are necessary for the treatment to work.
Analyses of autoantigens in a new form of endemic pemphigus foliaceus in Colombia.
89 Tissue transglutaminase (tTG) is the major autoantigen for celiac disease.
The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of stiff-man syndrome with breast cancer.
As well as being beta-cell specific, insulin is a secreted beta-cell autoantigen.