autoantigen


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Related to autoantigen: autoimmune disease, alloantigen, Autoantibodies

autoantigen

[¦ȯd·ō′ant·i·jən]
(immunology)
A tissue within the body which acquires the ability to incite the formation of complementary antibodies.
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References in periodicals archive ?
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.
The autoantibody repertoire in T1D was first investigated with an array of 87 autoantigens in a 96-well plate format.
Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behcet's disease.
9,13-18) Developments, such as the association of gastric MALT lymphoma with H pylori infection, the notion of acquired MALT, the biology of autoantigen activation and continuous somatic mutations, the documentation of genetic aberrations, for example, the discovery of the t(11;18)(q21;q21) chromosomal translocation in lymphomas of MALT, and the clinical implications of specific cytogenetic alterations, have been the subject of excellent reviews and will not be recapitulated to any degree.
Identification and partial characterization of a novel 105-kDalton lower lamina lucida autoantigen associated with a novel immune-mediated subepidermal blistering disease.
Gel Protein name (abbreviated) MOWSE Peptide Protein spot score count score (a) (b) Cl% (c) N1 Sorcin (P30626) 133 5 100 N4 Golgi autoantigen 90 24 99.
The expanded peptide-specific regulatory cells shut down the autoimmune attack by preventing aggressive autoimmune cells from being stimulated by either the peptide contained in the vaccine or by any other type 1 diabetes autoantigen presented simultaneously on the same antigen presenting cell.
Derfuss (Germany) identified contactin 2 as a novel autoantigen targeted by T cells and autoantibodies in MS in a pathological study and these cells contribute in the development of grey matter pathology.
ATX-MS-1467 consists of four short peptides that are derived from myelin basic protein, a key autoantigen in MS.
A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors.
Among the antibodies that have been identified in patients with EBV-related mononucleosis are those targeting the Sm autoantigen, which otherwise is considered specific for lupus.
Some research suggests that citrullinated extracellular fibrin in synovium is a significant autoantigen involved in the immune response in rheumatoid arthritis.