The vasoconstrictor response initiated by a1-adrenoceptor activation in arterioles appears to be very complex and also involves autocrine signaling
mediated by ATP release through pannexin channels.
Santa-Coloma, "Disruption of interleukin-1[beta] autocrine signaling
rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function," PLoS ONE, vol.
Resistance mechanisms include constitutive autocrine signaling
through EGFR or loss of the full-length BRAF V600E protein.
Because autocrine signaling
is not completely ruled out even in dissociated cells, it is possible that autocrine signaling
works differently between embryos of these two animals.
atRA is a pleiotropic, paracrine or autocrine signaling
molecule produced from vitamin A through oxidative reactions carried out by the cytosolic retinaldehyde dehydrogenases RALDHl, RALDH2, and RALDH3 (Duester 2008).
Human ejaculated spermatozoa have been observed to express and secrete insulin and leptin, demonstrating that they can regulate their metabolism by means of autocrine signaling
(Aquila et al.
A sampling of topics: endothelial mechanotransduction, interactions with the extracellular matrix in cellular mechanotransduction, nuclear mechanics and mechanotransduction, mechanotransduction through local autocrine signaling
, and micro- and nanoscale force techniques for mechanotransduction.