autolysosome


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autolysosome

[¦ȯd·ō′lī·sə‚sōm]
(cell and molecular biology)
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Impaired autolysosome formation correlates with Lamp-2 depletion: Role of apoptosis, autophagy, and necrosis in pancreatitis.
However, it seems that the autophagy process is not always associated with autolysosome formation and does not necessarily lead to apoptosis.
Autolysosome, referred to as late/degradative autophagic vacuoles and autolysosomes (AVd), had higher electron density than the cytoplasm as shown in Figure 1(a).
MCF-10A and MDA-MB-231 cells were cultured in the media as described above and then treated with autolysosome inhibitors bafilomycin A1 (0.
Examination with TEM showed these inclusions to be a continuum of phagolysosome profiles (which we have termed accumulation bodies) - from phagolysosomes containing possible autolysosome and other dinoflagellate debris, to those filled with densely flocculent material, to residual bodies containing haphazardly arranged, laminated, dense bundles of fibers with both loose and condensed appearances [ILLUSTRATION FOR FIGURES 4B and 4C OMITTED].
2]D [8-9] which helps in phagocytosis of Mtb followed by fusion of phagosomes with lysosomes to form autolysosomes and expression of lysosomal enzymes and reactive oxygen species.
Lesionai skin shows not only the paucity of keratin filaments but clear evidence of cytolysis, with numerous autophagosomes, autolysosomes, and disruption of organelles in the cellular cytoplasm.
Subsequently, lysosomes fuse with autophagosomes to generate autolysosomes, in which cellular constituents are broken down by acid hydrolases.
Damaged organelles or macromolecules are engulfed by autophagosomes that are enveloped by two layers of membranes, and these structures later fuse with lysosomes to form autolysosomes (Klionsky et al.
The fusion of autophagosome and lysosome to form acidic autophagy vacuoles, autolysosomes, is considered as a biomarker of autophagy (Mizushima et al.
5) It begins with the formation of autophagosomes, followed by autolysosomes.