Neuropathy

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Related to axonal neuropathy: axonal polyneuropathy

neuropathy

[nu̇′räp·ə·thē]
(medicine)
Any disease affecting neurons.

Neuropathy

 

a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.

REFERENCES

Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.

L. M. SHMAONOVA

References in periodicals archive ?
In this study we aimed to compare vasculitic neuropathy and axonal neuropathy without an identifiable cause because both groups show axonal degeneration in their pathology and a demyelinating hereditary neuropathy HNPP as a control group.
It is now classified into a) acute inflammatory demyelinating polyneuropathy and b) acute motor axonal neuropathy (2-4).
Two of deceased patients suffered from acute motor sensory axonal neuropathy (AMSAN), and 5 of them had AIDP Fifteen of 60 GBS patients were classified as acute motor axonal neuropathy (AMAN), among which there were no deaths.
The peroneal nerve in 15 and the tibial nerve in 14 subjects were not excitable, while the remaining electrophysiological findings were indicating axonal neuropathy.
The additional information in the Beery family is like the story in the Lupski family, where some people on one side of his family who had just one copy of the mutated genes had carpal tunnel syndrome and some on the other side of the family who had another mutated gene copy had axonal neuropathy (a disorder that affects the axon, the part of the neuron that extends away from the main body and carries messages to peripheral parts of the body).