axonal transport


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axonal transport

[ak¦sän·əl ′tranz‚pȯrt]
(neuroscience)
The movement of organelles and molecules down a nerve cell's axon to its terminals along its cytoplasmic microtubule network.
References in periodicals archive ?
Tau aggregates and tau missorting impair axonal transport, mitochondrial function, and cytoskeletal dynamics and elevate oxidative stress in AD in an A[sz]-independent manner.
External pressures of 20 to 30 mmHg have been shown to impair venous blood flow and retard axonal transport, while pressures of 130-150 mmHg cause a conduction block.
15) Neurotrophic factor deprivation induces the loss of RGCs after impaired axonal transport, (16) while neurotrophic factor supplementation reduces the loss of RGCs after optic nerve injury.
Neuronal cells function and survival strongly depend on proper mitochondria functionality and activity, since axonal transport, neurotransmitter releasing, and ionic gradient can be severely impaired by dysfunctional mitochondria [317, 318].
1982) Axonal transport of adenylate cyclase activity in normal and axotomized frog sciatic nerve.
Evaluation of retinal nerve fiber layer thickness and axonal transport 1 and 2 weeks after 8 hours of acute intraocular pressure elevation in rats.
Inhibition of axonal transport in nerves chronically treated with local anesthetics.
Our neurodegeneration-specific biomarkers, which provide dynamic measures of axonal transport deficits in degenerating brain cells, predict therapeutic response in neurological and neuromuscular disorders.
The concept of "double crush syndrome" states that compression at the distal part of a nerve (often without any anatomical cause related to the source of pain) may be affected by fiber damage at a higher level, resulting in disruption of axonal transport [1].
Since the elimination half-life of aluminum from the human brain is 7 years, this can result in cumulative damage via the element's interference with neurofilament axonal transport and neurofilament assembly.
Accordingly, it was suggested that electrical stimulation that occurred immediately after injection would affect HRP uptake at the nerve terminal, whereas electrical stimulation 8-16 h and 18-24 h after injection would affect the axonal transport and the process of inactivation of HRP within the soma, respectively.