azole


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Related to azole: azole antifungals, Echinocandins

azole

[′ā‚zōl]
(organic chemistry)
One of a class of organic compounds with a five-membered N-heterocycle containing two double bonds; an example is 1,2,4-triazole.
References in periodicals archive ?
Azole therapy failed to cure an AIDS patient who relapsed with CNS histoplasmosis while receiving maintenance itraconazole and weekly amphotericin B and an apparently immunocompetent patient who relapsed with meningitis while taking fluconazole.
dubliniensis clinical isolates are susceptible to azole derivatives, resistant strains have been recovered from oral cavities of human immunodeficiency virus (HIV)-infected patients with oropharyngeal candidiasis and prior exposure to fluconazole.
Copper azole type B was supplied by Arch Wood Protection.
Lipid amphotericin B is the preferred treatment for these seriously ill patients, followed by an azole if the patient stabilizes, but mortality is high, he said.
Use of an allylamine or azole antifungal depends on patient compliance and cost--allylamines are more costly but allow for shorter treatments
No physicians reported observing azole resistance in an azole-naive patient
Some studies suggested that the TR/L98H mutation acquired in the environment due to azole fungicides usage in agriculture.
Rosenson noted that, in his study, 62% of the HIV-infected patients on a contraindicated statin were taking a protease inhibitor, 29% were on gemfibrozil (Lopid), and the remaining handful were on other agents posing significant risk of drug interactions, including azole antifungals, calcium channel blockers, or cobicistat (Tybost).
However, demand for copper azole quickly surpassed that for ACQ and now dominates the wood preservation market due to its availability in a micronizable formulation.
Azole inhibition of CYP450 occurs relatively rapidly, but that does not mean that rhabdomyolysis will always occur immediately.
4) The azole group includes mainly triazoles and imidazoles.
The first-line treatment for trichosporonosis includes the use of azole antifungal agents, since Trichosporon spp.