azole


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Related to azole: azole antifungals, Echinocandins

azole

[′ā‚zōl]
(organic chemistry)
One of a class of organic compounds with a five-membered N-heterocycle containing two double bonds; an example is 1,2,4-triazole.
References in periodicals archive ?
hematologic malignancy) during treatment with azole antifungal agents, including CRESEMBA.
guilliermondii strains exhibited high rates of azole MICs above ECVs (fluconazole, 17%; voriconazole and posaconazole, 24%; Table 3).
Moreover, the widespread use of antifungal drugs has led to the development of drug-resistant isolates, and resistance to azole antifungals continues to be a significant problem in the common fungal pathogen C.
Copper penetration in the treated lumber was generally good for the lumber treated with copper azole and micronized copper azole, except in areas where impermeable heartwood or knots were close to the surface (Fig.
In such cases, an azole cream is the better treatment choice, because azoles will kill Candida, bacteria, and dermatophytes that are there, she said.
In a small retrospective study comparing voriconazole to other azoles (itraconazole and posaconazole), elevated fluoride levels were present only with voriconazole; additionally, the presence of an elevated fluoride level with voriconazole was independent of treatment duration (15).
azole antifungals in this pharmacologic class: clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Kuric), miconazole (Micatin), oxiconazole (Oxistat), sertaconazole (Ertaczo), and sulconazole (Exelderm).
Several mechanisms of resistance have been identified including modification of sterol synthesis pathways by the fungus, modification of enzymes to reduce the binding of azoles to fungal components, and increased efficiency of removal of the azole within fungal cells.
If COD is quite low and stable, limited introduction of the most bio-resistant azole can be explored provided no significant increase in microbial population results.
Early in 2009, Fagnou published a paper in JACS showing that "palladium-catalyzed direct arylation can be performed with a broad range of azine and azole N-oxides" He felt the process provided a useful alternative to cross-coupling techniques in the "synthesis of appropriate heterobiaryl compounds," a development of interest in the manufacture of medicinal compounds.
If the new European regulations are approved, most of the azole fungicides used to control crop diseases will be banned.
The papers here reflect current interest in Aspergillus, including research that is mapping nine of its species, with topics including a review of molecular phylogenetics, phylogeny and subgeneric taxonomy, the role of ochratoxin A in profiling and specialization, genomics and DHN-malanin conidial pigmentation, extracellular enzymes and utilization of plant matter, the presence of sexual genes, mycoviruses, Aspergillus in grapes and coffee, its genetic diversity, its DNA sequence, azole resistance, and its role in human keraomycosis.