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base excision repair

   Also found in: Acronyms, Wikipedia 0.01 sec.
base excision repair [′bās ek′siz·zhən ri‚per]
(cell molecular)
A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated.


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DNA damage checkpoint, HR, nonhomologous end-joining, interstrand DNA cross-link repair, translesion DNA synthesis, nucleotide excision repair, and base excision repair [see Supplemental Material, Table 1, available online (doi:10.
The base excision repair pathway repairs small isolated foci of DNA damage including reduced or oxidized single bases or fragments and small, nonbulky adducts.
The good news is that not all DNA lesions become pathogenic, as our cells (hard-workers, indeed) also contain mending functions for correcting the DNA injury, called base excision repair (BER).
 
 
 
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