basement membrane

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basement membrane

[′bās·mənt ′mem‚brān]
(histology)
A delicate connective-tissue layer underlying the epithelium of many organs.
References in periodicals archive ?
Anti-glomerular basement membrane disease (anti-GBM disease) and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis can coexist.
Closer examination revealed that the basement membranes in bromine-free larvae were abnormal, and the guts of the flies did not develop properly as a result.
The tubules show changes that are usually accompanied with glomerular alterations, and they include tubular atrophy, tubular apoptosis, and thickened tubular basement membranes with occasional splitting and lamination.
Histopathological examination revealed infiltration of the lymphocytes in the interstitial spaces, glomerular hypertrophy, basement membrane thickening and tubular necrosis with loss of their brush border in some of the proximal convoluted tubules in diabetic rats.
Some novel approaches to renoprotection include the use of antifibrotic agents, restoration of the glycosaminoglycan content of the basement membranes, inhibition of protein kinase C and inhibitors of advanced glycation end-products formation.
Sherwood says that the abundant, cheap, rapidly multiplying worms and their basement membranes enabled his team to do a variety of experiments to narrow down the genes and molecular signals in play.
Electron microscopy of a full-thickness skin biopsy showed scattered osmiophilic granules in the basement membranes of several vascular smooth-muscle cells.
Laminin is one of the main glycoproteins of the basement membrane and participates in a series of such biological phenomena such as adhesion, migration, cellular differentiation and the maintenance of the cytoskeleton upon its binding to several components of the matrix, such as collagen type IV, heparin sulphate and entacin (2-7).
In the 16 cases with positive glomerular C4d staining, 13 had diffusely granular deposition of C4d along the peripheral capillary loops and mesangial areas (Figure 2); 2 cases had diffuse granular deposition of C4d in the tubular basement membrane and mesangial matrix but not in the peripheral capillary loops; and 1 case had focal granular pattern of C4d deposition in the mesangium, peripheral capillaries, and tubular basement membrane.
Untreated hypertension boosts the risk of intrauterine growth restriction (IUGR) from two- to threefold through several mechanisms, including decidual vasculopathy, a prematurely "aged" placenta with thickened basement membranes in terminal villi, and impaired blood flow from the uterus to the placenta.
The main component of these basement membranes is type IV collagen, which is composed of three [alpha] chains that form a triple helix.
Type IV collagen is an important structural element in most basement membranes of C.