Soupir et al3 performed a multi-institutional retrospective analysis of cases of Ph+ AMLs and CML in blast crisis and showed that Ph+ AMLs differed from CML in blast crisis by different clinical pictures (no splenomegaly nor basophilia
in Ph+ AML), bone marrow morphology (lower cellularity and myeloid to erythroid ratio in Ph+ AML), cytogenetic findings (characteristic other chromosomal abnormalities usually found in CML were not seen in Ph+ AML), and response to chemotherapy (return to normal karyotype was observed in cases of Ph+ AML, whereas persistence of Ph+ was seen in CML); however, the median survival was similar between the 2 groups.
Both types of cells differ in size and basophilia
from the small, oval nuclei of hemocytes that circulate through the hemolymph space between adjacent air pockets of the book lung (Fig.
The differential diagnosis of CML includes granulocytic leukemoid reactions, chronic myelomonocytic leukemia (CMML), chronic neutrophilic leukemia (CNL), and reactive causes of eosinophilia, basophilia
, and monocytosis.
At various times after fetal death, nuclear basophilia
staining may be lost in the kidneys, liver, heart, lungs, gastrointestinal tract, adrenal gland, and trachea The earliest loss of basophilia
occurs is in the cortical tubules of the kidneys This change occurs approximately four hours after fetal death.
Condition DR (n = 18) QMH (n = 18) Basophilia
10 1 Macrophage aggregates 6 2 Spongiosis hepatis 3 0 Foci of cellular alteration 2 0 Table 2.
These changes included minimal degeneration of some proximal convoluted tubules, apoptosis, tubular basophilia
, tubular casts, increased mitotic figures, and mononuclear cellular infiltrates.
A skin biopsy showed slight basophilia
of the dermis sugg estive of diffuse calcim deposition which was confirmed with a von Kossa stain.
Small cell change, originally described as small cell dysplasia, (4) is defined as hepatocytes showing decreased cell volume, increased nuclear to cytoplasmic ratio, mild nuclear pleomorphism and hyperchromasia, and cytoplasmic basophilia
, giving the impression of nuclear crowding (Figure 2, A).
Results of a CBC count revealed marked leukocytosis characterized by marked heterophilia, marked eosinophilia, mild basophilia
, and low hematocrit.
3) In our laboratory routine, we had observed that basophilia
almost never matched optical microscope counts.
We studied relative weight, cell labeling indices, and pathologic changes such as hypertrophy in all tissues; a range of cytochrome P450 enzymes and palmitoyl coenzyme A oxidase in the liver; changes in the levels of plasma total triiodothyronine, total thyroxine, and thyroid-stimulating hormone (TSH) as markers of thyroid gland function; and hyaline droplet formation, tubular basophilia
, and the formation of granular casts in the kidney.
3) The MMPS also serves to discriminate crospovidone (polyvinyl-Npyrrolidone) from MCC, although this distinction is usually not as crucial because the identification of crospovidone can be readily made based on the corallike shape of the particle, its lack of birefringence, and its deep basophilia
with hematoxylin-eosin stain.