bcl-2


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bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
References in periodicals archive ?
Thus we conducted a study on Indian childhood HL to shed new light on the significance of expression of bcl-2 family members and p53 in relation with clinical and histological factors, EBV association and treatment response.
The Combination of a Histone Deacetylase (HDAC) Inhibitor with the BCL-2 Inhibitor GX15-070 Has Synergistic Antileukemia Effect by Inducing Both Apoptotic and Autophagic Pathways (1633: Saturday, December 6, 2008)
We have shown that breast tumours that have high levels of Bcl-2 respond well to treatment with ABT-737 when used in combination with a conventional chemotherapy drug," he added.
Researchers from around the world have requested to study Abbott's Bcl-2 family protein inhibitors, which is an indication of the potential value that ABT-263 might bring to the cancer research field," said John Leonard, M.
BAX was the first identified P53-regulated, proapoptotic Bcl-2 family member.
Topic: ABT-199: Novel Bcl-2 specific inhibitor updated results confirm substantial activity and durable responses in high-risk CLL.
Cytogenetic analysis was performed with fluorescence in situ hybridization to reveal gene rearrangements of BCL-2 (18q21), BCL-6 (3q27), and c-MYC (8q24) genes (Figure 3).
Loren Walensky, developed a compound modeled directly from the pro-apoptotic the death domain of BCL-2, the BIM BH3 domain.
Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells.
The Bcl-2 family proteins, which are expressed at high levels in many tumors, play a central role in regulating apoptosis and, consequently, in tumor formation, tumor growth and resistance to treatment.