The mice which were genetically-engineered to naturally produce large amounts of beta catenin
developed skin tumours and.
Proceeds will be used to fund further development of Avalon's lead oncology drug, AVN944, and the continued advancement of its Beta catenin
, Aurora pathway, Survivin and Myc inhibitor programs.
In vitro expansion of HSCs using Wnt or a downstream protein, called beta catenin
, was shown to increase the number of transplantable stem cells more than 100-fold.
Additional clinical programs are expected to ensue from the Beta catenin
and Aurora pathways programs which are both in the lead optimization stage.