Inhaled or injected adrenaline or ephedrine became widespread in the treatment of asthma and persisted until the development of more specific beta-2 agonists
such as salbutamol.
Previous studies showed that treatment with beta-2 agonists
, in particular salbutamol, might increase the incidence of cardiac arrhythmia at high doses in asthmatics (1, 2,8).
Since the patient has also had several exacerbation episodes, one can build an argument for using a combination of inhaled corticosteroid and long-acting beta-2 agonist
The beta-2 agonist
use was reduced by 95%, and the corticosteroid inhaler was reduced by 92%.
Overall, the results indicate that daily use of an inhaled short-acting beta-2 agonist
was associated [odds ratio (OR) = 1.
The report recommends that "regularly scheduled, short-acting inhaled beta-2 agonist
treatment should be kept to a minimum.
The report compared the use of the newer anti-inflammatory drugs with the more conventional asthma drugs, such as theophylline and the newer bronchodilators known as beta-2 agonists
Inhaled short-acting beta-2 agonists
and anticholinergic bronchodilators have positive effects.
1 Beta-2 Agonists
, Key Products World Sales ($m), 2008-2014
These patients generally maintain asthma control with daily use of a combination of inhaled corticosteroid and long-acting beta-2 agonist
, and having a short-acting beta-2 agonist
available for quick relief.
The most significant launches over the next ten years will be GSKs once-daily inhaled corticosteroid/long-acting beta-2 agonist
combination "Super Advair", Novartis long-acting, dual-action bronchodilator combination product, GSK's novel intranasal corticosteroid, Allermist and Mercks Singulair/PG-D2 combination product.
succeeded on the grounds of "obviousness" maintaining that it was a well-known and standard practice to use both a beta-2 agonist
and a corticosteroid together for simultaneous or sequential administration by inhalation in the treatment of respiratory disorders.