glucuronidase

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glucuronidase

[‚glü·kyə′rän·ə‚dās]
(biochemistry)
An enzyme that catalyzes hydrolysis of glucuronides. Also known as glycuronidase.
References in periodicals archive ?
MPS VII is a rare genetic, metabolic lysosomal storage disorder (LSD) caused by the deficiency of beta-glucuronidase, an enzyme required for the breakdown of the glycosaminoglycans (GAGs) dermatan sulfate, chondroitin sulfate and heparan sulfate.
In the case of isolates from mobile phone surfaces, we generally showed statistically significant correlations between increased resistance to 5-fluorocytosine, miconazole, fluconazole, ketoconazole, itraconazole and higher enzymatic activity of alpha-galactosidase, alpha-glucosidase, alpha-mannosidase, beta-glucuronidase, beta-glucosidase, chymotrypsin, naphthyl phosphohydrolase, fucosidase, lipase, and esterase lipase.
This discovery wasn't central to the purpose of the research, but the study published Tuesday noted the red flag it should have represented at the time: By the late 1960s, other scientific publications had found a positive association between higher levels of urinary beta-glucuronidase and bladder cancer.
Leonard McEwen, a British allergist who realized that beta-glucuronidase had antiallergenic properties.
Additively and synergistically, the elevated fecal beta-glucuronidase was deconjugating whatever little cytochrome p450 detoxification was taking place, leading to the inability to clear and thus the accumulation of ambient chemicals and internal toxins that could not be oxidized for conjugation; notice the dual effect of endotoxin-mediated blockade of cytochrome p450 along with increased enterohepatic recycling due to the elevated fecal beta-glucuronidase.
Alex and Gallant (2008) cite studies, which suggest that breastmilk is rich in beta-glucuronidase (increases uptake of unconjugated bilirubin).
30), (31) Reishi mushrooms limit the activity of beta-glucuronidase, an enzyme that is elevated in many liver conditions, including inflammation, cirrhosis, and jaundice.
The presence of six enzymes was established in parotid saliva: acid phosphatase, total esterases, cholinesterase, lipase, beta-glucuronidase, and lysozyme.
Chromogenic substrate in the medium detects the beta-glucuronidase enzyme that is highly specific to E.
1987, "GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion rnarker in higher plants," EMBO J.
The findings suggest that serum beta-glucuronidase may be a useful parameter for the activity and extent of pathogenesis in leprosy.
Inter-individual variability in expression and activity of human beta-glucuronidase in liver and kidney: consequences for drug metabolism.