lactam

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Related to beta-lactam: beta-lactamase, Beta-lactam Ring

lactam

[′lak‚tam]
(organic chemistry)
An internal (cyclic) amide formed by heating gamma (γ) and delta (δ) amino acids; thus γ-aminobutyric acid readily forms γ-butyrolactam (pyrrolidone); many lactams have physiological activity.
References in periodicals archive ?
SYN-004 is intended to block the unintended harmful effects of certain IV beta-lactam antibiotics within the GI tract and maintain the natural balance of the gut microbiome, potentially preventing the 453,000 C.
The MaxSignal Beta-Lactam ELISA Test Kit was developed to ease these concerns and assure that food is free of beta-lactam antibiotic residues.
Synthetic Biologics is developing SYN-004, a novel second generation oral enzyme drug candidate, to be co- administered with commonly used IV beta-lactam antibiotics and is intended to protect the gastrointestinal microflora (microbiome) from the harmful effects of such antibiotics, thus potentially preventing C.
Synthetic Biologics is developing SYN-004, a novel second generation oral enzyme drug candidate, to be co-administered with commonly used IV beta-lactam antibiotics and is intended to protect the gastrointestinal microflora (microbiome) from the harmful effects of such antibiotics, thus potentially preventing C.
In lab tests, graduate student Jiuyang Zhang prepared a cobaltocenium metallopolymer that greatly slowed the destructiveness of beta-lactamase on a model beta-lactam molecule (nitrocefin).
Amino glycosides and beta-lactams may be more effective when combined with another agent for initial therapy of these upper-tract infection patients.
HA-MRSA clones are characterized by multiple drug resistance beyond the beta-lactams to include many non-beta-lactams, primarily in specimens isolated from urinary and respiratory tracts.
Risk of emergence of Pseudomonas aeruginosa resistance to beta-lactam antibiotics in intensive care units.
With beta-lactam antimicrobials the goal of treatment is to maximise the time that the free serum concentration of the drug exceeds the MIC (T>MIC), with killing of bacteria being optimal at 4 - 5 times the MIC in vitro.
TD-1792 is a compound that combines the antibacterial activities of a glycopeptide and a beta-lactam in one molecule.
Only penicillin and its relatives, a drug family known as beta-lactam antibiotics, significantly raised the transporter concentrations in this neural tissue, the scientists report in the Jan.

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