beta-lactamase


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Related to beta-lactamase: beta-lactamase inhibitors, beta-lactamase resistant penicillin

beta-lactamase

[¦bād·ə ′lak·tə‚mās]
(microbiology)
A bacterial enzyme that catalyzes the hydrolysis of the lactam ring in some penicillin antibiotics, rendering them ineffective.
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References in periodicals archive ?
Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland.
Modification of the double-disk test for detection of enterobacteriaceae producing extended-spectrum and AmpC beta-lactamases.
Carbapenems have been used in clinical settings as a last resort for their broadspectrum antibacterial activity and stability against various beta-lactamases produced by Gram-negative bacteria including extended-spectrum betalactamases (ESBLs).
Protected in this patent are MethylGene's novel sulfonamidomethylphosphonates, which are inhibitors of beta-lactamases and methods of treating bacterial infection.
They ordered beta-lactamase inhibitors second most commonly, in about 30% of prescriptions.
That's a significant problem because many useful genes are 10 or more times as large as the beta-lactamase gene.
We have filed a PCT patent for the characterization of beta-lactamase activity by MALDI-TOF mass spectrometry with the title "Methods and means for characterizing antibiotic resistance in microorganisms".
This beta-lactamase inhibitor has the potential for an expanded spectrum against multi-drug resistant bacteria and could be a much needed option for patients suffering from difficult-to-treat infections.
Detection and molecular genetics of extended-spectrum beta-lactamases among cefuroxime-resistant Escherichia coli and Klebsiella spp.
NXL104, Novexel's broad spectrum class A and C beta-lactamase inhibitor, is the subject of one poster.
The most common resistance mechanism is the production of beta-lactamase enzymes that destroy the antibiotic.

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