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beta-lactamase

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.04 sec.
beta-lactamase [¦bād·ə ′lak·tə‚mās]
(microbiology)
A bacterial enzyme that catalyzes the hydrolysis of the lactam ring in some penicillin antibiotics, rendering them ineffective.


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In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase.
A penicillin antibiotic with beta-lactamase inhibitor, the new drug is indicated for the treatment of acute otitis media.
In view of the mixed flora that cause PTA and the increasing number of beta-lactamase-producing microorganisms, the use of antibiotics active against beta-lactamases has become more popular in clinical practice.
 
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