bioassay

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Bioassay

A method for the quantitation of the effects on a biological system by its exposure to a substance, as well as the quantitation of the concentration of a substance by some observable effect on a biological system. The biological material in which the effect is measured can range from subcellular components and microorganisms to groups of animals. The substance can be stimulatory, such as an ion increasing taxis behavior in certain protozoans, or inhibitory, such as an antibiotic for bacterial growth. Bioassays are most frequently used when there is a number of steps, usually poorly understood, between the substance and the behavior observed, or when the substance is a complex mixture of materials and it is not clear what the active components are. Bioassays can be replaced, in time, by either a more direct measure of concentration of the active principle, such as an analytical method (for example, mass spectrometry, high-pressure liquid chromatography, radioimmunoassay), or a more direct measurement of the effect, such as binding to a surface receptor in the case of many drugs, as the substance or its mechanism of action is better characterized.

Assays to quantitate the effects of an exposure model the effect of a substance in the real world. Complex biological responses can be estimated by laboratory culture tests, which use, for example, bacteria or cells cultured in a petri dish (usually to model an effect either on the organism of interest, such as bacteria, or on some basic cellular function); by tissue or organ culture, which isolates pieces of tissue or whole organs in a petri dish (usually to model organ function); or in whole animals (usually to model complex organismic relationships).

bioassay

[¦bī·ō′as‚ā]
(analytical chemistry)
A method for quantitatively determining the concentration of a substance by its effect on the growth of a suitable animal, plant, or microorganism under controlled conditions.
References in periodicals archive ?
Marc Maltas, managing director of Biotest (UK), said: "Our products are used in the treatment of life-threatening diseases such as disorders of the immune and coagulation systems as well as critically ill patients or those undergoing organ transplantation.
Biotest Diagnostics Corporation can be contacted at 66 Ford Road, Suite 131, Denville, NJ 07834, or reached by telephone at (201) 625-1300.
Biotest Pharmaceuticals is a wholly-owned subsidiary of Biotest AG, a German global provider of plasma products.
Biotest Pharmaceuticals Corporation, a wholly owned subsidiary of Biotest AG, a German global provider of plasma therapies, researches, develops and manufactures biotherapeutic products with a specialization in immunology and hematology.
July 2, 2014 /PRNewswire/ -- Biotest Pharmaceuticals Corporation (BPC), a leading developer of immunology biotherapeutic products, is pleased to announce the addition of its newest plasma collection center located at 311 North Patterson Road, in Valdosta, Georgia.
ImmunoGen's collaborative partners include Amgen, Bayer Schering Pharma, Biogen Idec, Biotest, Genentech (a member of the Roche Group), Novartis, and sanofi-aventis.
May 21, 2014 /PRNewswire/ -- Biotest Pharmaceuticals Corporation (BPC), a leading developer of immunology biotherapeutic products, announced today that it has opened its 15th U.
3, 2013 /PRNewswire/ -- Biotest AG, Dreieich, Germany and EpiVax, Inc.
The World Federation of Hemophilia (WFH), in partnership with Canadian Blood Services (CBS) and two manufacturers of plasma products, BIOTEST AG and GRIFOLS, will officially announce the launch of Project Recovery during the WFH Global Forum on the safety and supply of treatment products for bleeding disorders in Montreal, Canada, on September 26.
19, 2013 /PRNewswire/ -- Biotest Pharmaceuticals Corporation ("Biotest"), a wholly owned US subsidiary of Biotest AG, (Dreieich Germany), announced today that it has been awarded the 2013 International Business Leadership Award for "Business Expansion" from the Greater Miami Chamber of Commerce.
30, 2013 /PRNewswire/ -- Biotest Pharmaceuticals Corporation (BPC), a leading developer of immunology biotherapeutic products, has opened its 14[sup.