Although ranitidine (Zantac) is compatible with pregnancy, both the salt form ranitidine bismuth citrate
(Tritec) and bismuth alone are best avoided because the limited human data prevent an accurate assessment of bismuth's risk to the embryo or fetus.
Seven-day triple therapy of ranitidine bismuth citrate + clarithromycin + metronidazole or amoxicillin For these therapies, a high-quality systematic review of 8 studies reported eradication rates of 81% (95% CI, 77%-84%) with amoxicillin and 88% (95% CI, 85%-90%) with metronidazole.
PPI + clarithromycin + (metronidazole or amoxicillin), or ranitidine bismuth citrate + clarithromycin + (metronidazole or amoxicillin).
metronidazole, or clarithromycin, plus either ranitidine bismuth citrate, bismuth subsalicylate, or a proton pump inhibitor.
Ranitidine bismuth citrate (RBC) 400 mg BID + clarithromycin 500 mg TID x 2wks then RBC 400 mg BID x 2 wks
4 Mechanism of Action of Bismuth Citrate
and CBS on H.
pylori infection were randomized to receive 500 mg clarithromycin plus 400 mg ranitidine bismuth citrate