Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh
extract in Chinese women with menopausal symptoms: A randomized, double blind, parallel-controlled study versus tibolone.
There were 56 women in the black cohosh
group and 60 women in the Tibolone group.
For better evaluation of the varied results from clinical trials, it is necessary to examine the long-term stability of black cohosh
and whether this might change over the duration of a clinical trial, which typically takes multiple years to accrue the full complement of subjects and to run all to completion.
Study participants used an average daily oral preparation of 40 mg of black cohosh
for an average of 23 weeks.
AS nearly all black cohosh
sold commercially is collected from natural forest populations, the potential for harvesting impacts is considerable (Chamberlain et al.
Some research suggests that black cohosh
is no better than placebo at improving hot flashes.
Data from a recent metaanalysis showed that although there was significant heterogeneity between included trials, preparations containing black cohosh
improved vasomotor symptoms overall by 26% (95% CI, 11%-40%).
In 2006, a double-blind, randomized, placebo-controlled study was done using a combination trial of black cohosh
Larimore placed soy extracts and two German extracts of black cohosh
sold in the United States under the brand names Remifemin and Klimadynon.
Second was black cohosh
(46%), followed by soy supplements and food (42%), antidepressants (32%), meditation and relaxation (26%), evening primrose oil (17%), and blood pressure medications (14%), Some respondents said they used more than one therapy.
But overall, survey respondents perceived antidepressants to be one of the most effective methods, followed by homeopathy, meditation and relaxation, evening primrose, blood pressure medications, black cohosh
, soy products, and multivitamins and calcium.
However, we do find trends, most notably sharp declines in sales of women's supplements like soy and black cohosh
, as well as declines in calcium sales, which skew heavily toward women concerned about osteoporosis.