blastoma

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blastoma

[‚bla′stōm·ə]
(medicine)
A tumor whose parenchymal cells have certain embryonal characteristics.
A true tumor.
References in periodicals archive ?
Because of these changes in diagnostic criteria, the literature reported before the 1999 and 2004 WHO classifications needs to be reviewed critically to determine if fetal adenocarcinomas may have been included in studies of pulmonary blastomas.
The malignant elements differ from those seen in blastomas in that they lack the blastemal primitive appearance and histologically resemble adult-type carcinomas and sarcomas.
The glands in blastomas stain with antibodies to keratin, TTF-1, carcinoembryonic antigen, surfactant, and EMA.
Neuroendocrine differentiation is found in two-thirds of pulmonary blastomas.
Pulmonary blastomas have been shown to have [beta]-catenin mutations, varying percentages of p53 mutations, but no KRAS mutations.
While both blastomas and carcinoid tumors show neuroendocrine differentiation, carcinoid tumors do not consist of either purely glandular or biphasic glandular and sarcomatous elements.
Blastomas can be biphasic with epithelial and sarcomatous elements; however, carcinosarcomas do not show a primitive blastemal component.
In the 2004 World Health Organization (WHO) classification, (2) sarcomatoid carcinoma is used as an overall term for a spectrum of tumors that includes pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma, and blastoma.
Pulmonary blastoma is a biphasic tumor containing a malignant epithelial component resembling fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma, or rhabdomyosarcoma.
If a small biopsy specimen shows only a fetal adenocarcinoma pattern, one cannot exclude the possibility of a biphasic pulmonary blastoma, realizing the blastematous component may not have been sampled.
The presence of malignant stroma is the primary feature distinguishing pulmonary blastoma from well-differentiated fetal adenocarcinoma.