blood clotting


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blood clotting,

process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings. To control bleeding from vessels larger than capillaries a clot must form at the point of injury. The coagulation of the blood is also initiated by the blood platelets. The platelets produce a substance that combines with calcium ions in the blood to form thromboplastin, which in turn converts the protein prothrombin into thrombin in a complex series of reactions. Thrombin, a proteolytic enzyme, converts fibrinogen, a protein substance, into fibrin, an insoluble protein that forms an intricate network of minute threadlike structures called fibrils and causes the blood plasma to gel. The blood cells and plasma are enmeshed in the network of fibrils to form the clot. Blood clotting can be initiated by the extrinsic mechanism, in which substances from damaged tissues are mixed with the blood, or by the intrinsic mechanism, in which the blood itself is traumatized. More than 30 substances in blood have been found to affect clotting; whether or not blood will coagulate depends on a balance between those substances that promote coagulation (procoagulants) and those that inhibit it (anticoagulantsanticoagulant
, any of several substances that inhibit blood clot formation (see blood clotting). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other
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). Prothrombin, a substance essential to the clotting mechanism, is produced by the liver in the presence of vitamin K. When the body is deficient in this vitamin, bleeding is more difficult to control. In hemophiliacs, or "bleeders," the blood's coagulation time is greatly prolonged (see hemophiliahemophilia
, genetic disease in which the clotting ability of the blood is impaired and excessive bleeding results. The disease is transmitted through females but almost invariably affects male offspring only.
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). The coagulation of blood within blood vessels in the absence of injury can cause serious illness or death, especially when a clot forms in the coronary arteries (thrombosisthrombosis
, obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted.
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) or cerebral arteries (strokestroke,
destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called apoplexy.
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 or apoplexy). To prevent coagulation of the blood in persons with known tendency to clot formation, and also as prophylaxis before performing surgery or blood transfusion, the blood's natural anticlotting substance, heparin, is reinforced by an additional amount of an anticoagulant such as Dicumarol injected into the body.
References in periodicals archive ?
The findings offer new targets for the development of drugs to regulate blood clotting, he added.
More than two million patients in the United States take warfarin to prevent blood clotting after cardiovascular events such as heart attack and stroke, for prophylaxis of clot formation in the setting of major surgery and for the treatment of other clotting disorders.
This potential effect on blood clotting "is a theoretical concern, not yet seen," says Fitzgerald.
Drugs based on the Chrysalin peptide can be used to mimic part of the thrombin response without stimulating the events associated with blood clotting and therefore have the potential to accelerate the natural cascade of healing events.
Our new test, the ThromboProfile(TM), measures platelet reactivity and the tendency for blood clotting in a patient, the most common events that occur before a heart attack or stroke.
He and Zheng propose that vitamin E quinone inhibits carboxylase by binding to the site on the enzyme where vitamin K--which activates the blood clotting cascade--normally attaches.
NASDAQ: TLIO) announced that its compound, TP-9201, has been shown by independent researchers to prevent blood clotting without increasing bleeding time in animal models of heart attack and thrombosis.
bioMerieux receives a $ 1 million license fee for access to its markers for blood clotting disorders