anticoagulant

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anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Pradaxa (dabigatran) is a popular blood thinner medication taken to prevent blood clots that lead to stroke and even death.
To learn more about Xarelto, Pradaxa, and other blood thinner cases, including services in helping you find a Xarelto lawyer or Xarelto law firm, visit: http://lawsuitssettlementfunding.
Injured consumers have claimed Pradaxa[R] manufacturer, Boehringer Ingelheim aggressively marketed the blood thinner as a safe alternative to existing blood thinners without taking patient safety into account.
Right now I am on a blood thinner and am looking at using aspirin instead.
Now, she has me on a medicine to slow my heart rate, and a blood thinner.
Medco is also collaborating with the Mayo Clinic on a study of the blood thinner warfarin and with Laboratory Corporation on a study of tamoxifen, a treatment for breast cancer.
The blood thinner is among five drugs for which Bristol-Myers is seeking Food and Drug Administration approval by 2012, the company said in March.
s blockbuster drug Plavix currently dominate the blood thinner market.
New York) halted a trial of their experimental blood thinner after an increase in bleeding outweighed benefits for patients who recently suffered a heart attack or severe chest pain.
SeeNews) - Nov 8, 2012 - Anglo-Swedish pharma major AstraZeneca plc (LON:AZN, STO:AZN) said its blood thinner Brilinta is efficient even when studied with more sensitive methods than in the PLATO trial, which served as basis for regulatory approvals.
He is taking a blood thinner to reduce the chance of future clotting and is expected to remain hospitalized for seven to 10 days.
Edwards: Your research team found that 80% of potential adverse drug events were associated with the blood thinner warfarin.