anticoagulant

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anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Blood thinners help prevent blood clots that can form in the legs and travel to the lungs, causing a potentially life-threatening pulmonary embolism, or that form in the heart due to the abnormal heart rhythm atrial fibrillation (these clots can travel to the brain, causing a stroke).
More than one in three atrial fibrillation (AF) patients at intermediate to high risk for stroke were treated with aspirin alone, despite previous data showing this therapy to be inferior to blood thinners, according to researchers at the University of California (UC) San Diego and UC San Francisco schools of medicine.
Injured consumers have claimed Pradaxa[R] manufacturer, Boehringer Ingelheim aggressively marketed the blood thinner as a safe alternative to existing blood thinners without taking patient safety into account.
The blood thinner is now approved under the name Brilinta in 39 countries, also including Brazil, Australia and Canada.
s blockbuster drug Plavix currently dominate the blood thinner market.
The blood thinner is among five drugs for which Bristol-Myers is seeking Food and Drug Administration approval by 2012, the company said in March.
The second is to control the heart rate and use a blood thinner to prevent blood clots, which is what your doctor is doing now.
Right now I am on a blood thinner and am looking at using aspirin instead.
Bureau of Alcohol, Tobacco and Firearms harmed any vodkas carrying bison grass extracts, due to it containing coumarin, a natural blood thinner.
But taking a blood thinner requires some work, since it is necessary to maintain enough drug in the blood to prevent unwanted blood clots without increasing the risk of bleeding.
If you can't take a blood thinner, a small filter can be inserted into a large vein in your abdomen--the vena cava--to prevent a clot from reaching your lungs.
com)-- Wright & McGurk Law announced today that they are accepting new Pradaxa blood thinner injury cases.