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barrier |
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barrier 1. a. an exposed offshore sand bar separated from the shore by a lagoon b. (as modifier): a barrier beach 2. that part of the Antarctic icecap extending over the sea barrier [′bar·ē·ər] (ecology) Any physical or biological factor that restricts the migration or free movement of individuals or populations. (navigation) Anything which obstructs or prevents passage of a craft. (physics) Barrier [′bar·ē·ər] (ordnance) A passive acoustic detection system for submarines, consisting of hydrophones positioned on the ocean floor and connected by undersea cable to a land-based computer center. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Blood-Brain Barrier (BBB) research embodies the true meaning of a "translational model" of neuroscience wherein breakthroughs in basic neuroscience are delivered to the clinic and require an agent delivery strategy and/or the ability to target specific areas of the brain. Long recognized as "the A in ADME", pION has commercialized PAMPA and developed applications that are highly correlated with Caco-2, gastrointestinal tract (GIT) and blood-brain barrier (BBB) permeation. Two accessory mechanisms are also suggested to be involved in MCS, one involving nitric oxide and the other peroxynitrite:nitric oxide inhibition of cytochrome P450 activity and peroxynitrite-mediated increased permeability of the blood-brain barrier (BBB) (Pall 2002b; Pall and Satterlee 2001). |
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