and nevus of Ota associated with dural melanoma.
Because NCH may resemble a blue nevus
both clinically and histopathologically, it should always be considered in the differential diagnosis, despite its rarity.
Also, the melanocytes of the blue nevus
tend to be more slender than the plumper tumor cells of the hyalinizing Spitz nevus.
Distinguishing epithelioid blue nevus
from blue nevus
-like cutaneous melanoma metastasis using fluorescence in situ hybridization.
Such lesions include blue nevus
, melanosis, and malignant melanoma.
In a subset of DPNs, scattered pigmented dendritic melanocytes can be seen and, in this context, distinction from a variant of blue nevus
may be difficult.
1,2) This review focuses only on blue nevus
and its variants.
Almost a decade ago, the authors independently recognized that a subset of darkly pigmented melanocytic metastasizing tumors histologically reminiscent of melanomas occurring in animals, sometimes referred to as socalled animal-type melanomas, are histologically very similar to benign epithelioid blue nevus
described in patients with Carney complex and also occurring sporadically, unassociated with the syndrome.
They also discuss in great detail the relationship of pigmented epithelioid melanocytoma and epithelioid blue nevus
of Carney complex.
Most variants of cutaneous nevi including combined nevus, balloon cell nevus, Spitz nevus, pigmented spindle cell nevus, and blue nevus
have been reported in the conjunctiva.
In view of the results of a clinicopathologic analysis of 40 patients with tumors previously diagnosed as "animal-type or pigment-synthesizing melanoma" or "epithelioid blue nevus
," Zembowicz et al (101) proposed the term pigmented epithelioid melanocytoma (PEM) to encompass these melanocytic tumors.
Bland-appearing (pseudobenign) lesions can resemble a variety of other spindle cell proliferations, particularly proliferating scars and sclerosing blue nevus