The researchers knew that a protein called PRDM16 played some part in converting a myoblast into a brown fat cell
, but they had a problem.
The newly isolated beige fat cells are a type of brown fat cell
that is distinct from the classic brown fat most highly studied in small mammals and human infants.
The gene regulator micro-RNA 155 inhibits a certain transcription factor that controls brown fat cell
For quite some time now, researchers have been trying to develop drugs that can either boost the activity of brown fat cells
or transform white fat cells into tissue that behaves similarly to brown fat, in order to harness brown fat's properties for weight loss.
Brown fat cells
burn energy at a much higher rate than white fat.
Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells
In a small laboratory study, University of Florida researchers found that the hormone irisin can help transform calorie-storing white fat cells into energy-burning brown fat cells
Histologic sections demonstrated cytologically bland brown fat cells
with abundant granular cytoplasm identical to the preoperative biopsy (Figure 5).
In the new paper, Kajimura s team collaborated with the laboratory of Yasushi Ishihama, PhD, of the University of Kyoto, Japan, to search for differences in how white and brown fat cells
respond to the cold using a technique called phosphoproteomics.
Researchers at Leiden University Medical Centre, Netherlands, reckon artificial lights disrupt our body clocks and the brown fat cells
that burn calories.
Black pepper contains piperine, which affects whether precursor fat cells mature into white fat cells that store calories or brown fat cells
that burn calories.
Unlike brown fat cells
that form distinct anatomical depots, newly identified and isolated beige fat cells, which are interspersed within white adipose tissues, arise from a different developmental lineage from the brown fat cells
and have dual functions regulating both energy storage and energy dissipation (1).