in young patients: a retrospective study of 74 cases.
Experimental bullous pemphigoid
generated in mice with an antigenic epitope of the human hemidesmosomal protein BP230.
Asbrink E, Hovmark A: Clinical variations in bullous pemphigoid
with respect to early symptoms.
Kirtschig G, Middleton P, Bennett C, Murrell DF, Wojnarowska F, Khumalo NP: Interventions for bullous pemphigoid
Development of bullous pemphigoid
during treatment of psoriasis with adalimumab.
Delaporte E, Dubost-Brama A, Ghohestani R et al: IgE autoantibo-dies directed against the major bullous pemphigoid
antigen in patients with a severe form of pemphigoid.
These cells play a role in the development of certain inflammatory diseases, including ulcerative colitis, Crohn's disease, severe asthma and bullous pemphigoid
Ongoing patient enrollment process for Phase II in Bullous Pemphigoid
(BP) and Ulcerative Colitis (UC) with Bertilimumab
Immune's lead product candidate, bertilimumab, is in phase II clinical development for moderate to severe ulcerative colitis as well as for bullous pemphigoid
, an orphan auto-immune dermatological condition.
Neil Korman, MD, PhD, Professor of Dermatology, University Hospitals, Case Medical Center, Cleveland, OH, said, "An autoimmune blistering disease, Bullous Pemphigoid
, has no real treatments beyond powerful anti-inflammatory medicines called corticosteroids.
The dipeptidyl peptidase-IV inhibitors are the newer drugs linked to the most potentially serious side effects, namely, drug-induced bullous pemphigoid
The disorders include SLE, antiphospholipid syndrome (APS), Sjogren's syndrome, systemic sclerosis (SSc), Still's disease, AAV, Behcet's disease, cryoglobulinemia, poly/dermato-myositis, scleroderma, as well as pemphigus vulgaris, bullous pemphigoid
, epidermolysis bullosa, ITP, and thrombotic thrombocytopenic purpura.