calcium pump


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Related to calcium pump: plasma membrane calcium pump

calcium pump

[¦cal·se·əm ‚pəmp]
(cell and molecular biology)
An enzyme that uses the energy generated by the hydrolysis of adenosine triphosphate (ATP) to move calcium ions out of the cytoplasm or, in the case of muscle cells, from the cytoplasm to the sarcoplasmic reticulum. Also known as Ca2+ATPase.
References in periodicals archive ?
However, when they blocked glycolysis, they saw a reduced supply of ATP which inhibited the calcium pump, resulting in a toxic calcium overload and ultimately cell death.
It turns out that the calcium pump can accurately measure the cell's calcium content and adjust its speed in accordance with this information.
Our group was the first to isolate the active ingredient, thapsigargin, elucidate its chemical structure and demonstrate that it kills tumor cells by blocking a specific intracellular calcium pump.
Leading researchers from Aarhus University and the University of Copenhagen have now provided new information of how the calcium pump regulates the amount of calcium in the cells.
CALCIUM PUMP PROTEINS--Proteins on the sarcoplasmic reticulum that remove calcium from the cell cytosol after a contraction.
This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump (SERCA) and its role in genesis of arrhythmias.
Celladon is developing both biologics and small molecules targeting a key enzyme deficiency in advanced heart failure, the sarcoplasmic reticulum calcium pump (SERCA2a), which promote contractility but without the negative consequences of current inotropic therapies.
Furthermore, memory formation and retrieval were amended both by calcium chelation as a therapy and by pharmaceutical inhibition of internal calcium pumps.

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