However, when they blocked glycolysis, they saw a reduced supply of ATP which inhibited the calcium pump
, resulting in a toxic calcium overload and ultimately cell death.
It turns out that the calcium pump
can accurately measure the cell's calcium content and adjust its speed in accordance with this information.
In young hearts, these calcium pumps
work quite well, but in older hearts these pumps are much less efficient.
Our group was the first to isolate the active ingredient, thapsigargin, elucidate its chemical structure and demonstrate that it kills tumor cells by blocking a specific intracellular calcium pump
Leading researchers from Aarhus University and the University of Copenhagen have now provided new information of how the calcium pump
regulates the amount of calcium in the cells.
PROTEINS--Proteins on the sarcoplasmic reticulum that remove calcium from the cell cytosol after a contraction.
This review mainly focuses on the structure, function of the sarco(endo)plasmic reticulum calcium pump
(SERCA) and its role in genesis of arrhythmias.
Celladon is developing both biologics and small molecules targeting a key enzyme deficiency in advanced heart failure, the sarcoplasmic reticulum calcium pump
(SERCA2a), which promote contractility but without the negative consequences of current inotropic therapies.
Furthermore, memory formation and retrieval were amended both by calcium chelation as a therapy and by pharmaceutical inhibition of internal calcium pumps