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calcium-channel blocker

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.01 sec.
calcium-channel blocker, any of a class of drugs used in treating hypertension hypertension or high blood pressure, elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
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, angina pectoris angina pectoris (ănjī`nə pĕk`tərĭs)
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, and certain arrhythmias arrhythmia (ārĭth`mēə), disturbance in the rate or rhythm of the heartbeat.
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. They prevent the calcium ions needed for muscle contraction from entering the cells of smooth and cardiac muscle. This causes blood vessel walls to relax and blood to flow more freely to the heart, lowering blood pressure and relieving anginal pain. Some calcium-channel blockers, such as Procardia (nifedipine), slow the electrical impulses that run through heart muscle, thus regulating arrhythmias. Cardizem (diltiazem) is a common calcium-channel blocker.


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We found a significant interaction between use of calcium-channel blocker and P[M.
The first study tested the diuretic chlorthalidone against the ACE inhibitor lisinopril and amlodipine, a calcium-channel blocker.
Combination drug therapy with calcium-channel blockers in the treatment of systemic hypertension.
 
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