calsequestrin


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calsequestrin

[¦kal·sə¦kwes·trən]
(cell and molecular biology)
An acidic protein, with a molecular weight of 44,000, which binds calcium inside the sarcoplasmic reticulum.
References in periodicals archive ?
Other potential orbital antigens include thyroglobulin and cholinesterase epitopes, the flavoprotein subunit of the mitochondrial succinate dehydrogenase, a 55 kDa protein (G2s), calsequestrin and others (8-11).
Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression.
For a long time, researchers have been studying the molecular defects that trigger arrhythmias and knew that the disorder is caused by mutations in two genes that encode calcium-handling proteins- the ryanodine receptor and calsequestrin.