camptothecin


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camptothecin

[‚kam·tō′thē·sən]
(pharmacology)
An alkaloid belonging to the family of drugs called topoisomerase inhibitors which is used as an anticancer drug, it is the first known naturally produced DNA topoisomerase inhibitor and was originally isolated from the Chinese tree Camptothecin acuminate.
References in periodicals archive ?
Sites of accumulation of the antitumor alkaloid camptothecin in Camptotheca acuminata.
Patterns of accumulation of camptothecin, an anticancer alkaloid in Nothapodytes nim-moniana Graham.
Both Irinotecan and Hycamtin (Topotecan) are derivatives of camptothecin (CPT) and target Topo I enzyme as Topo I poisons.
Aphios has utilized its patented SuperFluids[TM] CFN technologies to develop nanosomal formulations of paclitaxel (Taxosomes[TM]), camptothecin (Camposomes[TM]) and other poorly water-soluble therapeutics.
Methanolic extracts of leaves, leaf-derived callus, root-derived callus, bilobalide and Tanakan inhibited tumor formation significantly, but more weakly than the positive control, camptothecin.
One of the key implications of the Phase 1 study is that Cerulean's nanopharmaceutical platform technology has successfully transformed camptothecin into a clinical development candidate.
XMT-1001 is a conjugate of the anti-cancer molecule camptothecin (CPT) that employs Mersana's Fleximer platform.
XMT-1001 is a polymer-based prodrug of camptothecin (CPT), a well-characterized topoisomerase I inhibitor with potent anti-tumor activity.
The order of activity was: camptothecin paclitaxel = vinblastine < podophyllin = vincristine.
a clinical-stage biopharmaceutical company focused on developing oncology therapeutics, today announced the dosing of the first patient in a Phase II clinical study of its third-generation camptothecin compound, AR-67, in patients with Glioblastoma Multiforme (GBM), an aggressive form of brain cancer.
Derivatives of the anticancer agent camptothecin, such as Camptosar(R), have been successful but their true clinical potential has been limited by safety issues," commented Robert J.