Sites of accumulation of the antitumor alkaloid camptothecin
in Camptotheca acuminata.
Patterns of accumulation of camptothecin
, an anticancer alkaloid in Nothapodytes nim-moniana Graham.
Predictable release kinetics of camptothecin
that is largely enzyme independent.
Both Irinotecan and Hycamtin (Topotecan) are derivatives of camptothecin
(CPT) and target Topo I enzyme as Topo I poisons.
Aphios has utilized its patented SuperFluids[TM] CFN technologies to develop nanosomal formulations of paclitaxel (Taxosomes[TM]), camptothecin
(Camposomes[TM]) and other poorly water-soluble therapeutics.
Methanolic extracts of leaves, leaf-derived callus, root-derived callus, bilobalide and Tanakan inhibited tumor formation significantly, but more weakly than the positive control, camptothecin
One of the key implications of the Phase 1 study is that Cerulean's nanopharmaceutical platform technology has successfully transformed camptothecin
into a clinical development candidate.
XMT-1001 is a conjugate of the anti-cancer molecule camptothecin
(CPT) that employs Mersana's Fleximer platform.
XMT-1001 is a polymer-based prodrug of camptothecin
(CPT), a well-characterized topoisomerase I inhibitor with potent anti-tumor activity.
The order of activity was: camptothecin
paclitaxel = vinblastine < podophyllin = vincristine.
a clinical-stage biopharmaceutical company focused on developing oncology therapeutics, today announced the dosing of the first patient in a Phase II clinical study of its third-generation camptothecin
compound, AR-67, in patients with Glioblastoma Multiforme (GBM), an aggressive form of brain cancer.
Derivatives of the anticancer agent camptothecin
, such as Camptosar(R), have been successful but their true clinical potential has been limited by safety issues," commented Robert J.