Bile stasis is most prominent in the canaliculi
, without accompanying inflammation or necrosis .
They may cause inflammation or fibrosis of canaliculi
or intrahepatic bile ducts, obstructing flow of bile from the liver (cholestasis).
The histologic features of nasolabial cysts show striking similarity to the physiologically encountered epithelia in the lacrimal drainage system, specifically the lacrimal canaliculi
and sac and the nasolacrimal duct that drain tear fluid from the eye to the inferior meatus of the nose (Figure 1).
According to Robertson and Bradley (1992), the canaliculi
of Salmo salar are formed by 3 to 4 hepatocytes, and these cells do not feature filaments in the pericanalicular cytoplasm, as noted in some other teleosts (Weis, 1972; Hampton et al.
Another mechanism leading to cholestasis is mediated by drugs that bind to actin filaments, resulting in disruption of the actin filaments situated around the bile canaliculi
, thus preventing the normal pulsatile contractions that move bile through the canalicular system to the bile ducts (Cullen 2005).
The resulting WIF-B cell line expressed both alcohol dehydrogenase and cytochrome P450 2E1, maintained polarity, and formed functional bile canaliculi
(Shanks et al.
Retention of bile acids leads to solubilization of cholesterol and phospholipids in the cellular membranes of hepatocytes and the biliary canaliculi
Data indicated that treatment with SCY-635, which is a weak inhibitor of MRP2, resulted in fewer indications of hyperbilirubinemia--including lower accumulation into hepatocytes, greater efflux into bile canaliculi
and reduced inhibition of hepatic efflux transporters than the cyclosporin-based cyclophilin inhibitors NIM811 and Debio-025.
QTS' B-CLEAR technology refers to a patented methodology that, when applied to properly functioning hepatic cells, opens the bile pockets (analogous to bile canaliculi
in vivo), allowing material that has been transported from inside the cell to be measured.
A scar near the area of the medial canthus, may point to previous trauma which may have involved the canaliculi