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(organic chemistry)
C10H12O4 Colorless crystals that melt at 218°C; slightly soluble in acetone, chloroform, alcohol, and water; used in veterinary medicine. Also known as cantharides camphor.



the active principle of Spanish flies and other bugs of the family Meloidae (blister beetles); a terpenoid anhydride of cantharidic acid. Cantharidin is poorly soluble in water and readily soluble in fats and organic solvents. It severely blisters the skin and mucous membranes. It causes pain, a burning sensation, and formation of blisters. Ingestion causes poisoning, accompanied by catarrh of the urinary tract, salivation, vomiting, diarrhea, abdominal pain, and excitation of the central nervous system.

References in periodicals archive ?
Cantharidin (exo, exo-2, 3-dimethyl-7-oxobicyclo [2.
maximum is unknown, but a previous research ruled out the possibility that the disease is caused by oxalates or saponins contained in the pasture or by contamination by Pithomyces chartarum or insects of the genus Epicauta producers of cantharidin (CERQUEIRA et al.
viii) myosin light chain phosphatase, MLCP (dephos-phorylates MLC) [inhibitor cantharidin (3a,7a-dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione), 10 [micro]mol [1.
11) There is no consensus about the dosage and duration in current therapy modalities, but some experts suggest liquid cantharidin (0.
4] Bulgakov VP, Tchernoded GK, Mischenko NP, Khodakovskaya MV, Glazunov VP, Radchenko SV, Zvereva EV, Fedoreyev SA & Zhuravlev YN (2002) Effect of salicylic acid, methyl jasmonate, ethephon and cantharidin on anthraquinone production by Rubia cordifolia callus cultures transformed with the rolB and rolC genes.
For facial warts, she said she prefers tretinoin cream, and for periungual warts, cantharidin (blister beetle extract).
erosion due to podofilox, imiquimod, cantharidin, fluorouracil, or podophyllin toxin) Aphthous ulcer Atrophy Bartholin's abscess Candidiasis Carcinoma Chronic irritant contact dermatitis Endometriosis Herpes (simplex and zoster) Immunobullous diseases (including cicatricial pemphigoid, pemphigus vulgaris, linear immunoglobulin A disease, etc.
In the order Coleoptera, only Meloidae, Oedemeridae and Staphylinidae release vesicant chemicals that cause dermatitis and conjunctivitis (the first two release cantharidin and the latter, pederin).
Silverberg NB, Sidbury R, Mancini AJ: Childhood molluscum contagiosum:Experience with cantharidin therapy in 300 patients.
Stwff o'r enw cantharidin sy'n yr olew, a hwn sy'n codi'r pothelli, ac mae'n medru achosi chwydd ar y croen hefyd.
Blister beetles and false blister beetles are medically important because they produce the chemical cantharidin that causes skin blistering.