capillary gel electrophoresis


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capillary gel electrophoresis

[¦kap·ə·ler·ē ¦jel i‚lek·trō·fə′rē·səs]
(analytical chemistry)
A form of capillary electrophoresis in which a polyacrylamide gel (or other polymeric material) is placed inside the capillary and separation is based on size and charge; often used to separate oligonucleotides and proteins.
References in periodicals archive ?
Capillary gel electrophoresis (CGE) in molecular pathology and genetics is an ideal instrument for fast, fully automated analysis.
12,13) Alternatively, for techniques like capillary isoelectric focussing and capillary gel electrophoresis the electroosomotic flow is eliminated.
Guttman held appointments at Diversa Corporation (San Diego, CA) developing novel separation methods for bioindustrial scale carbohydrate analysis, at the Torrey Mesa Research Institute (La Jolla, CA) on microfluidics, Genetic BioSystems (San Diego, CA), on microgel electrophoresis and Beckman Coulter (Fullerton, CA) on capillary gel electrophoresis.
Here we report a quantitative PCR method, followed by separation by capillary gel electrophoresis of the fluorescently labeled amplified exons of hot spot regions of the dystrophin gene, which allowed us to detect ~99% patients (affected males and female carriers) with macrodeletions and 89% with macroduplications, and to identify small insertions or deletions in those regions.
High-performance capillary gel electrophoresis is an instrumental approach with the capability of a single-base resolution (16,17).