Guttman held appointments at Diversa Corporation (San Diego, CA) developing novel separation methods for bioindustrial scale carbohydrate analysis, at the Torrey Mesa Research Institute (La Jolla, CA) on microfluidics, Genetic BioSystems (San Diego, CA), on microgel electrophoresis and Beckman Coulter (Fullerton, CA) on capillary gel electrophoresis
Here we report a quantitative PCR method, followed by separation by capillary gel electrophoresis
of the fluorescently labeled amplified exons of hot spot regions of the dystrophin gene, which allowed us to detect ~99% patients (affected males and female carriers) with macrodeletions and 89% with macroduplications, and to identify small insertions or deletions in those regions.
High-resolution capillary gel electrophoresis
of reducing oligosaccharides labeled with 1-aminopyrene-3,6,8-trisulfonate.
Because our method does not rely on restriction digestion, it has distinct advantages over other Apo E capillary gel electrophoresis
Prediction of migration behaviour of oligonucleotides in capillary gel electrophoresis