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It is shown to significantly reduce chemotherpay resistance in a preclinical model of lung cancer in combination with carboplatin.
As a pre-surgery treatment, the women were randomly assigned to receive either standard chemotherapy (a combination of paclitaxel, adriamycin, and cyclophosphamide), standard chemotherapy plus carboplatin, standard chemotherapy plus Avastin (a drug that blocks cancers from generating blood vessels), or standard chemotherapy plus both carboplatin and Avastin.
2] of docetaxel (Taxotere) intravenously for 1 hour on days 1 and 8, combined with carboplatin (AUC=6) IV on day 1, and repeated every 3 weeks for six cycles.
Those patients given carboplatin experienced fewer side effects and were able to get back to their normal lives quicker than the men on radiotherapy, the research found.
Giving patients a carboplatin injection is less unpleasant with fewer longterm risks.
In the study, 573 patients were randomized to a single dose of carboplatin given over one hour on an outpatient basis and 904 were randomized to a course of daily radiotherapy given over two or three weeks.
The median overall survival time for patients in the Avastin plus carboplatin and paclitaxel arm was 12.
carboplatin against carboplatin (a platinum-based chemotherapy) alone in
The most common adverse reactions (20%) of ABRAXANE in combination with carboplatin for NSCLC are anemia, neutropenia, thrombocytopenia, alopecia, peripheral neuropathy, nausea, and fatigue.
The new approvals are for use of trastuzumab (a) as part of a treatment regimen containing doxorubicin, cyclophosphamide, and docetaxel, and (b) as part of a regimen that includes docetaxel and carboplatin.
Drugs, such as poly(ADP-ribose) polymerase inhibitors and the platinum-based chemotherapy drug carboplatin, have been shown to be effective against BRCA2 tumors in early laboratory trials.
In the late-stage study, patients received Nexavar in combination with chemotherapeutic drugs carboplatin and paclitaxel.