carboxyl terminal


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carboxyl terminal

[kär′bäk·səl ′tər·mən·əl]
(biochemistry)
The end of a polypeptide chain with a free carboxyl group.
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Abbreviations: ADP: adenosine diphosphate; AMPPNP: [beta],[gamma]-imidoadenosine 5'-triphosphate; ATP: adenosine triphosphate; BFP: blue fluorescent protein; COOH-terminal: carboxyl-terminal; C-domain: carboxyl terminal domain; EGTA: ethylene glycol tetraacetic acid; GFP: green fluorescent protein; N-domain: aminoterminal domain; NH-terminal: amino-terminal; Pi: inorganic phosphate; S1: subfragment 1 of myosin; TnC: troponin-C; TnI: troponin-I; TnT: troponin-T; Tn[T.
Second generation immunoassays, called intact PTH analysis, have a system of two antibodies, one specifically for the carboxyl terminal portion and one for the amino terminal portion of the molecule.
In the cFGF-23 assay, antibodies detect 2 different epitopes in the carboxyl terminal portion.
GP96 is the most abundant member of HSP90 in the endoplasmic reticulum (ER), contains an N-terminal signal sequence (70 amino acid), characteristic of the ER-targeted proteins and a carboxyl terminal KDEL sequence (Lys-Asp-Glu-Leu), which is a retention/retrieval signal from the golgi to the ER.