Carboxylation

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carboxylation

[kär‚bäk·sə′lā·shən]
(organic chemistry)
Addition of a carboxyl group into a molecule.

Carboxylation

 

the direct introduction of the carboxyl group —COOH to organic compounds by the action of CO2. For example, carboxylation of organometallic compounds occurs during the passage of CO2 through a solution of the compound; subsequent hydrolysis yields carboxylic acid:

Salicylic acid and ^-aminosalicylic acid (PASA), used in medicine, are obtained through a singular carboxylation process involving the corresponding phenolates, for example

Carboxylation in an organism is effected by specific enzymes, forexample, pyruvate carboxylase catalyzes the carboxylation ofpyruvic acid. Carboxylation plays an important role in the oxida-tion of intermediate products of the decomposition of carbohy-drates, fats, and proteins in the organism.

References in periodicals archive ?
Under acidic pH (pH < 4), most of the carboxylate are protonated and hydrophobic interactions dominate.
1(b)] can be attributed to C=O stretching in carboxamide functional groups and symmetric and asymmetric stretching modes of carboxylate groups, respectively.
The carboxylate is the only major metabolite and the principal degradation product (7,8).
Cu(I) Carboxylate + Oxygen [right arrow] Cu(II) Carboxylate + Cu(I) Oxide
In the first set of paints, the dispersant level was kept at 1% of pigment solids as the % of carboxylate in the dispersant was varied.
Hepatic and/or intestinal esterases convert the phosphate to the active carboxylate form of drug, [greater than or equal to] 75% of the latter reaching the systemic circulation.
The stability of the lactone plus carboxylate forms of irinotecan and its four metabolites in plasma and saliva was determined by use of QC samples at concentrations of 0.
Since 1980, CSM complimented its portfolio with nickel chemicals and since 2007 with a broad range of metal carboxylates for various catalytic applications.
NEW YORK, May 26, 2015 /PRNewswire/ -- Calcium stearate, one of the most commonly used metallic stearate for industrial and commercial applications, is a nontoxic and non-irritating carboxylate of calcium.
1] are attributed to the asymmetric and symmetric stretching vibration of the carboxylate group [6, 16, 28-30], The bands at 1023 and 1079 [cm.
and combinations thereof and an electrodepositable binder, the binder is comprised of resin(s) comprised of a phosphorous-containing group in which X is a hydrogen, a monovalent hydrocarbon or an oxygen atom having a single covalent bond to the phosphorous atom, and each oxygen atom has a covalent bond to a hydrogen atom, an alkyl group, an aryl group, an alkylaryl group, an arylalkyl group, or the resin or one of the resins, with the caveat that at least one oxygen atom has a covalent bond to the resin or one of the resins; a carboxylate group separated by from 2-4 carbons from an ester group; and a tridentate amine ligand.
1] is due to C=O asymmetric stretching in carboxylate anion that is reconfirmed by another peak at 1411 [cm.