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The deterioration of existing defense mechanisms, leading to an exacerbation of pathologic behavior.



disturbance of the activity of an organ, a system of organs, or the entire organism, as a result of exhaustion or disruption of its adaptive mechanisms.

Harmful influences that cause significant changes in the organism disturb the constant equilibrium between the organism and the external environment. After some time, the organism adapts itself to the new conditions of existence (for example, the heart muscle hypertrophies when there are heart defects) and equilibrium is restored—that is, compensation occurs. When there is compensation, the organ (or system) works under an increased load, as a result of which it succumbs more readily to harmful influences.

References in periodicals archive ?
Both our patients and cases from the literature (4) also showed a dramatic effect of carnitine treatment, which demonstrates that cardiac decompensation can be avoided in MCD-deficient patients.
At index time, all participants were hospitalized for an episode of cardiac decompensation.
Similarly, patients with SOB/WK may have been symptomatic because of underlying diseases other than cardiac decompensation (e.
A 76-year-old woman was admitted for cardiac decompensation, hypertension, and renal failure.
Her cardiac decompensation resolved over several days and an ejection fraction of 70% was noted on echocardiogram 10 weeks after her admission.
Having detected a murmur in the mitral valve of the patient's heart, the pulmonologist believed that the patient was most likely suffering from a mitral-valve disease that was causing cardiac decompensation.
Although this may be difficult in a patient with longstanding lung disease and superimposed cardiac decompensation, in the majority of patients the diagnosis can be made with the exchange of a few words followed by an examination of the neck veins, chest, abdomen, and lower extremities.
In deciding on the method of anaesthesia for caesarean section or analgesia for labour, the risks of the various techniques must be considered in light of the patient's condition, in particular the presence of spinal AVMs or acute cardiac decompensation, with few publications about the anaesthetic management of parturients with high output cardiac failure secondary to AVMs.