cardiac glycoside


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Related to cardiac glycoside: digitalis, digoxin

cardiac glycoside

[‚kärd·ē‚ak ′glī·kə‚sīd]
(biochemistry)
A class of naturally occurring glycosides that exhibit the ability to strengthen the contraction of heart muscles.
References in periodicals archive ?
Cardiac glycosides are chemically similar to digoxin, and are distributed throughout the plant, either fresh or dried (LANGFORD & BOOR, 1996; SOTO-BLANCO et al.
Thus, we selected and continued detailed molecular analysis of cardiac glycoside induced cell death in liver cancer cells using Lanatoside C.
Cardiac glycosides help improve symptoms of congestive heart failure, but do not necessarily lower the rate of patient mortality (Adams & Holland, 2011).
12) In summary, cardiotoxic plant poisonings may cause serious dysrhythmias and death and will require intensive care management with combinations of gastrointestinal decontamination with oral-activated charcoal, intravenous vasopressor support, anti-arrhythmics, temporary pacemaker or temporary cardiopulmonary bypass, and few specific antidotes, with the exception of digoxin-specific Fab in cases of confirmed cardiac glycoside poisonings.
Interestingly, these events occur at nontoxic (nanomolar) concentrations, well below the concentrations of any reported toxic complications encountered with therapeutic cardiac glycoside doses.
Currently, heart failure patients are treated with diuretics such as furosemide to reduce water volume; cardiac glycosides such as digoxin, which produce a positive inotropic effect in cardiac muscles to improve cardiac output; inhibitors of the renin-angiotensin-aldosterone system such as angiotensin converting enzyme inhibitors; and medications that block [beta]-adrenergic receptors to the deleterious effects of neurohormones.
A cardiac glycoside obtained from the leaves of Digitalis Iantana.
The kernel of its fruit contains various toxic principles; the important one is Cerberin, a cardiac glycoside almost similar to digitalis in its toxicity.
5,6) Digoxin is a cardiac glycoside that inhibits Na/K-ATPase, thus causing a transient increase in intracellular sodium and then an increase in calcium by way of the sodium-calcium exchange mechanism.
Acid detoxification resulted in reduction in the cardiac glycoside content from 4.