Doctors suspended injections of a cardiotonic drug
early Wednesday, Fukushima said.
Observed effects of crude Hawthorn extract and cardiotonic drugs
on cardiomyocytes Start-up Arrhythmia Drug name Effect on rate observed promotion Hawthorn extract (tablet Decrease Yes No batch 1) (30-300 18 of 22 1 of 22 [micro]g/ml) Epinephrine (5-50 [micro]M) Increase Yes Yes 14 of 17 15 of 17 Propranolol (10-50 [micro]M) Decrease No Yes 0 of 15 12 of 15 Ouabain (20-500 [micro]M) Increase Inconclusive Inconclusive 6 of 21 12 of 21 Milrinone (10-20 [micro]M) Increase Inconclusive Inconclusive PBS (vehicle) No effect No No 0 of 8 1 of 12 Effects on cardiomyocyte contraction rate are summarized from the results shown in Fig.
The dead animals obtained from these acute experiments presented with their hearts stopped in systolic stand-still, the characteristic toxic response for cardiotonic drugs
(Arul et al.