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Related to carnitine acetyltransferase: carnitine palmitoyltransferase


C7H15NO3α-Amino-β-hydroxybutyric acid trimethylbetaine; a constituent of striated muscle and liver, identical with vitamin B T.



betaine-γ-amino-β-oxybutyric acid, (CH3)3NCH2CH(OH)CH2CO2, a crystalline compound with basic properties; dissolves readily in water and alcohol. Its molecular mass is 161.21, and its melting point, 195°-197°C (with decomposition).

Carnitine is primarily found in animal muscle, from which it was first extracted by V. S. Gulevich (1905); it is also found in bacteria and plants. It takes part in fatty exchange within an organism by acting as a carrier of fatty acid radicals through the membranes of the mitochondria. These membranes are impermeable to activated fatty acids (compounds with coenzyme A). With the aid of carnitine, therefore, fatty acids enter the scope of activity of the oxidizing enzymes localized within the mitochondria. Carnitine apparently also participates in the reverse transport of fatty acids. It is an essential dietary constituent and a growth factor in certain insects; therefore it is considered to be a vitamin (vitamin BT).

References in periodicals archive ?
One may therefore postulate that increased activities of fatty acid synthetase, ketoglutarate, glucose-o-phosphate dehydrogenase, and carnitine acetyltransferase may be part of an adaptive response of megakaryocytes to the increased influx of glucose through the GLUT 3 glucose transporter (Table 2) (9).
L-carnitine has been reported to increase acetyl-CoA provision for fatty acid synthesis in the liver and for fatty acid and acetylcholine production in the brain (3,16), apparently through activation of the carnitine acetyltransferase pathway (3,16).
Acetylcarnitine is produced by the mitochondrial matrix enzyme, carnitine acetyltransferase (CrAT).