caspase


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Related to caspase: Caspase 3, Caspase 9

caspase

[′kas‚pās]
(cell and molecular biology)
Any of a family of intracellular proteins that mediate apoptosis.
References in periodicals archive ?
Concentration-dependent processing of initiator (caspase-9 and -8) and the executioner (caspase-3) caspases was also observed, indicating that the intrinsic and the extrinsic pathways play an important role in the mechanism of cell death.
Although these studies demonstrated that an anti-caspase strategy may be a promising novel treatment for sepsis, the potential risk of hyper-acute TNF-induced shock (58) and a lack of specificity of doses needed for such inhibition (49,59) remain the primary stumbling blocks for caspase inhibitors to be used clinically.
Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.
Compounds that can either inhibit caspases or induce caspases may form the basis for important new drugs for a wide variety of disease targets, such as cancer, cardiovascular disease and other degenerative diseases.
We also demonstrated that these effects of rosamultic acid were mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases in these cells.
Idun's lead compound, IDN-6556, a first-in-class pan caspase inhibitor, is in Phase II clinical trials in liver transplantation and in patients infected with Hepatitis C virus.
In a prospective study of 59 randomly selected patients with chronic hepatitis C virus (HCV) infection, a high degree of inflammatory liver injury on liver biopsy was associated with greater levels of the products that result from the cleavage of cytokeratin-18 (CK-18, a major intermediate filament protein in liver cells) by caspases during apoptosis (Hepatology 2004;40:1078-87).
Promega Corporation announces the expansion of bioluminescent caspase assays with the release of Caspase-Glo[R] 2 and 6 Assays that will enable new insights to their physiological roles in apoptosis.
This was prevented by the non-specific caspase inhibitor z-VAD-fmk, and reduced by the selective caspase-3/7 inhibitor z-DEVD-fmk.
These data suggest that quercetin may induce apoptosis by direct activation of caspase cascade through mitochondrial pathway and ER stress in PC-3 cells.

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