cataplexy


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cataplexy

[′kad·ə‚plek·sē]
(medicine)
Sudden loss of muscle tone provoked by exaggerated emotion, such as excessive anger or laughter, often associated with a profound desire for sleep.
Prostration by the sudden onset of disease.
Hypnotic sleep.
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Nasdaq: ARNA) announced today the initiation of patient screening in a Phase 1 clinical trial of APD916, a novel oral drug candidate discovered by Arena that targets the histamine H3 receptor for the treatment of narcolepsy and cataplexy.
And the possible value of Sodium oxybate (aka: GHB or Xyrem[R]) in alleviating cataplexy associated with narcolepsy.
If a patient has experienced EDS > 3 months and reports at least 5 episodes of cataplexy a sleep study and MSLT does not need to be performed.
For children and young adults, especially, narcolepsy and its symptoms, such as cataplexy, sleep paralysis and night terrors, can be horrifying, daily incidents, bringing on intolerable depression, sometimes leading to thoughts of suicide.
The committee voted by an 8-1 margin that sodium oxybate should be prescribed only for those patients who have received a diagnosis of cataplexy.
Many sufferers also experience episodes of cataplexy, brief but debilitating periods of muscle weakness or complete physical collapse usually brought on by emotions such as laughter or surprise.
Cataplexy, sleep paralysis, and hypnagogic hallucinations are thought to be the result of REM sleep phenomena (e.
Symptoms of cataplexy and/or hypnagogic hallucinations require additional agents such as sodium oxybate, SSRI's or tricyclic antidepressants.
Xyrem (sodium oxybate) oral solution is the only product approved by the United States Food and Drug Administration for the treatment of both cataplexy and excessive daytime sleepiness in patients with narcolepsy.
The effects of cataplexy range from dropping of the jaw and slumping of the head to buckling of the legs and even the collapse of the whole body, and can last for several minutes.
The Company's lead product is Xyrem, which is the first and only approved treatment for cataplexy associated with narcolepsy.
Cataplexy can range from slight weakness or a drooping of the face to the complete loss of muscle tone and is triggered by strong emotional reactions such as laughter, anger or surprise.