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cathepsin |
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cathepsin [kə′thep·sən] (biochemistry) Any of several proteolytic enzymes occurring in animal tissue that hydrolyze high-molecular-weight proteins to proteoses and peptones. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Flatworms taken from mice treated with the drug showed reduced activity of the cysteine protease called cathepsin B, suggesting that this enzyme is a prime target of K11777. Neutrophils exhibit defective chemotaxis and reduced intracellular killing for up to 90 minutes after bacterial phagocytosis, and their granules lack the serine proteases cathepsin G and elastase because of a failure of normal protein sorting (68,69). Since papain is closely related to cathepsin B, a thiol endopeptidase which is released by cells of the inflammatory response, the authors concluded that segmented poly-etherurethanes can be degraded by enzymes which are present during the inflammatory response. |
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