But if the triptan is unable to curb this process and ascending pain signals activate the trigeminal nucleus caudalis
, it's game on: The resultant central sensitization is beyond the reach of that medication class.
15,16) On the other hand, the pontine part of the trigeminal nucleus pars caudalis
is supposed to play a key role in eliciting migraine headache.
Later, it was shown that nucleus pontis caudalis
(NPC) (48) as well as nucleus pontis oralis (NPO) (49) are involved in cortical activation.
In the brain of male medaka, high levels of activity are localized in sections containing the preoptic (POA) and suprachiasmatic nuclei (SC) (63-75 fmol/hr) and low levels in the nuclei periventricular dorsalis (HD), ventralis (HV), and caudalis
(Hc), nuclei diffusus of lobulus inferiores (NDIL), and nuclei tuberi anteriores (TA) and posteriores (TP) ([is less than] 25 fmol/hr).