cell cycle


Also found in: Dictionary, Thesaurus, Medical, Legal, Financial, Wikipedia.
Related to cell cycle: cell division, mitosis, meiosis

Cell cycle

The succession of events that culminates in the asexual reproduction of a cell; also known as cell division cycle. In a typical cell cycle, the parent cell doubles its volume, mass, and complement of chromosomes, then sorts its doubled contents to opposite sides of the cell, and finally divides in half to yield two genetically identical offspring. Implicit in the term “cycle” is the idea that division brings the double-sized parent cell back to its original size and chromosome number, and ready to begin another cell cycle. This idea fits well with the behavior of many unicellular organisms, but for multicellular organisms the daughter cells may differ from their parent cell and from each other in terms of size, shape, and differentiation state.

The time required for completion of a eukaryotic cell cycle varies enormously from cell to cell. Embryonic cells that do not need to grow between divisions can complete a cell cycle in as little as 8 min, whereas cycling times of 10–24 h are typical of the most rapidly dividing somatic cells. Many somatic cells divide much less frequently; liver cells divide about once a year, and mature neurons never divide. Such cells may be thought of as temporarily or permanently withdrawing from the cell cycle.

Eukaryotic phases

The cell cycle is divided into two main parts: interphase and mitosis (see illustration). During interphase, the cell grows and replicates its chromosomes. Interphase accounts for all but an hour or two of a 24-h cell cycle, and is subdivided into three phases: gap phase 1 (G1), synthesis (S), and gap phase 2 (G2). Interphase is followed by mitosis (nuclear division) and cytokinesis (cell division). This relatively brief part of the cell cycle includes some of the most dramatic events in cell biology.

Phases of the eukaryotic cell cycleenlarge picture
Phases of the eukaryotic cell cycle

G1 phase

Gap phase 1 begins at the completion of mitosis and cytokinesis and lasts until the beginning of S phase. This phase is generally the longest of the four cell cycle phases and is quite variable in length. During this phase, the cell chooses either to replicate its deoxyribonucleic acid (DNA) or to exit the cell cycle and enter a quiescent state (the G0 phase).

S phase

Replication of the chromosomes is restricted to one specific portion of interphase, called S phase (DNA synthesis phase), which typically lasts about 6 h. In mammalian cells, the start of S phase—the actual initiation of DNA synthesis—takes place several hours after the cell has committed to carrying out DNA synthesis. During S phase, each chromosome replicates exactly once to form a pair of physically linked sister chromatids. In animal cells, a pair of centrioles is also duplicated during S phase. See Chromosome, Genetics

G2 phase

The portion of interphase that follows S phase is called gap phase 2. Some cells can exit the cell cycle from G2 phase, just as they can from G1 phase.

M phase

M phase includes the overlapping processes of mitosis and cytokinesis. Mitosis is divided into five stages: prophase, prometaphase, metaphase, anaphase, and telophase. Cytokinesis usually begins during anaphase and ends at a point after the completion of mitosis. At the end of cytokinesis, the parent cell has formed its two G1 phase progeny and the cell is ready to repeat the cycle. See Cytokinesis, Mitosis

Control of cell cycle

The network of proteins that regulate DNA synthesis (G1/S), mitotic entry (G1/M), and mitotic exit (the transition from mitotic metaphase to anaphase and then out of mitosis) appears to be well conserved throughout eukaryotic evolution. At the heart of these cell cycle transtions is the periodic activation and inactivation of cyclin-dependent protein kinases. In addition, in multicellular eukaryotes, pathways regulating entry into and exit from the cell cycle entrain these central cyclin-dependent kinases to extrinsic signals.

cell cycle

[′sel ‚sī·kəl]
(cell and molecular biology)
In eukaryotic cells, the cycle of events consisting of cell division, including mitosis and cytokinesis, and interphase.
References in periodicals archive ?
Analysis of cell cycle arrest: To measure cell cycle arrest induced by culture supernatant and lysate, 60 mm tissue culture plates were seeded with HeLa cells (2 x [10.
Restriction point--p53 is a protein that functions to block the cell cycle if the DNA is damaged.
The cell cycle is a key cellular process that fails to function normally in cancer development.
BRCA-1 and -2 are important proteins for breast cancer progression by regulating cell cycle and DNA damage.
The polycomb genes have an essential role in embryogenesis, regulation of the cell cycle, and lymphopoieisis.
For such cancers, at least three mutations would have to occur: Both copies of either BRCA1 or BRCA2 would have to go bad, and additional mutations would have to strike genes regulating the cell cycle.
Therefore, we investigated the cellular mechanisms underlying the cell cycle arrest and apoptosis induced by daidzein in human breast cancer MCF-7 and MDA-MB-453 cells.
MKC-1 is a novel, orally-active cell cycle inhibitor with in vitro and in vivo efficacy against a broad range of human solid tumor cell lines, including multi-drug resistant cell lines.
At low doses, genistein acted as a weak estrogen and stimulated cell growth; at high doses, the compound inhibited proliferation and altered cell cycle dynamics.
Occasionally, particularly in older organisms, cells with defective BRCA I or BRCA2 genes would also experience mutations in the genes needed to arrest the cell cycle.

Full browser ?