cell permeability

Cell permeability

The permitting or activating of the passage of substances into, out of, or through cells, or from one cell to another. These materials traverse either the cell surface that demarcates the living cytoplasm from the extracellular space or the boundaries between adjacent cells. In many cases the materials also traverse the cell wall. See Cell walls (plant)

The cell can control many properties of its membranes, including those related to permeability. Control can be exerted in the following ways: (1) by varying the number and variety of membranes; (2) by varying the specific nature of the lipid components in the membrane; (3) by varying the glycocalyx proteins or lipid-associated sugar molecules on the outside of the cell, or the membrane-associated proteins on the inside; (4) by causing large areas of membrane to flow from one place to another, or to fold, indent, evert, or pinch off, carrying with these movements substances bound to one or the other surface of the membrane, or embedded in it; (5) by selectively moving integral membrane proteins in the plane of the membrane, allowing these proteins to carry with them substances, particles, molecules, or other materials bound to them; (6) by varying the properties of a single integral membrane protein or of a closely associated group of them so as to allow or prevent the passage across the membrane of substances such as ions or proteins of a specific character. See Cell membranes

cell permeability

[′sel pər·mē·ə′bil·əd·ē]
(cell and molecular biology)
The permitting or activating of the passage of substances into, out of, or through cells.
References in periodicals archive ?
APT(TM) works by enhancing bacterial cell permeability and susceptibility to alcohol, allowing inactivation and killing of microorganisms on the skin surface and stratum corneum.
As important, TOGA(TM)'s identification of novel mechanisms of targeted drug entry and absorption will enhance Elan Pharmaceutical Technologies' leadership edge in the study of new approaches to issues of cell permeability and drug absorption enhancement.
The Target Activation BioApplication is a general and versatile investigative tool that will empower researchers to gather a wealth of cellular information about the activity of specific targets, including, but not limited to, measurement of multiple drug resistance, cytoplasmic pH, intracellular ion concentrations, mitochondrial transmembrane potential, GFP expression, cell permeability and membrane potential.
Thiovir is intended to deliver all of the benefits of the FDA-approved drug foscarnet, including broad spectrum antiviral activity, with the added benefit of improved cell permeability.
These scientifically selected and validated inhibitors ensure cell permeability, reversibility and potency.
The libraries supplied by Chemical Diversity Labs are widely known for having diverse scaffolds as well as side chains, and using their technologies, CDL was able to generate a library for us that was both highly diverse and had high cell permeability, which is an important factor for successful drug development from initial hits.
In preclinical studies, Aileron's Stapled Peptide[TM] compounds have been shown to possess compelling potency, in vivo stability and cell permeability.
Biphasic effect of danazol on human vascular endothelial cell permeability and f-actin cytoskeleton dynamics.
TRT's research intends to identify how SoftWave technology aids intracellular communication and enhances the delivery of cancer fighting medications through increased cell permeability.
The key roles that membrane proteins play in cell signaling, cell permeability and motility make them prime targets for drug developers and biologists studying the fundamental processes of cells, tissues and organs," states Tamara Zemlo, Ph.
In preclinical studies, Aileron's Stapled Peptide Therapeutics have been shown to possess remarkable potency, in vivo stability and cell permeability.
In VRE, changes in cell permeability and the resulting dissipation of the membrane potential is likely the primary mechanism.