Jude Childrens Research Hospital and Fred Hutchinson Cancer Research Center have developed an algorithm that predicts T cell recognition
of antigens and sets the stage to more effectively harness the immune system.
The Swansea University cancer cell recognition
research is an international collaboration with the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, USA, Helmholtz Zentrum Munchen in Munich, Germany, The Francis Crick Institute in London and Newcastle upon Tyne University.
A molecular basis for NKT cell recognition
of CD1d-self-antigen," Immunity, vol.
The study (1) reported that new cell recognition
software had a sensitivity of 95% and a specificity of 88% for immature myeloid cells.
Glycomics is the study of carbohydrates and carbohydrate-containing biomolecules in biological processes such as cell recognition
, immune response, cell-to-cell interaction, infection and inflammation.
The newly identified mode of cancer cell recognition
by the immune system opens up new possibilities for leukaemia immunotherapy.
EpCAM, the protein chosen by the Heidelberg immunologists as the tumour cell recognition
structure, is a characteristic membrane protein of epithelial cells.
This study showed that ELISPOT responses might demonstrate T cell recognition
of HIV-specific antigen, but are not useful biomarkers to predict the efficacy of a candidate HIV therapeutic vaccine.
With the discovery of these sequences, QI believes that dendritic cell recognition
of the foreign cancer protein can be more efficient and specific, and will therefore result in a more effective immunotherapy treatment against malignancy.
These include the down-regulation of class I molecule on the surface of host cells to escape cytotoxic T cell recognition
by utilizing the unique short region protein (US), US2, US3, US6, and US11.
Of the methods currently used to recognize and isolate types of individual cells for biochemical or functional studies, the most widely used are fluorescence-activated cell recognition
techniques such as fluorescence imaging (4), flow cytometry (5-7), and magnetically activated cell sorting [e.
NCAM is perhaps the most widely studied of the cell surface glycoproteins involved in the process of cell recognition
(Sanes, 1989; Schachner and Martini, 1995).